Jinrong Huang , Liping Xiao , Hui Zhao , Fuwei Liu , Lihui Du
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Pooled analysis utilized the random-effects model with inverse variance and included adjusted hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs).</p></div><div><h3>Results</h3><p>The meta-analysis comprised a total of 8 studies, which consisted of 5 prospective cohort studies and 3 retrospective cohort studies. The total population under consideration included 11,686,677 individuals without T2DM, of whom 54.3% were female. Among this population, 396,368 individuals developed T2DM. To account for heterogeneity, a random-effects model was employed. Overall, the pooled data demonstrated a significant association between living alone and an increased risk of T2DM when compared to living with others (HR 1.24, 95% CI 1.06–1.46). Subgroup analysis revealed that this risk was not statistically significant for either males (HR 1.28, 95% CI 0.93–1.76) or females (HR 1.06, 95% CI 0.84–1.33), nor in prospective cohort studies (HR 1.26, 95% CI 0.91–1.74) or retrospective cohort studies (HR 1.26, 95% CI 0.91–1.74).</p></div><div><h3>Conclusion</h3><p>Individuals living alone faced a significantly higher risk of developing diabetes compared to those who did not live alone. However, no significant difference in this risk was observed between genders and study types. 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引用次数: 0
摘要
背景：独居是一个普遍存在的心理问题，已被发现对生活方式和健康状况有重大影响。虽然已有大量研究探讨了独居与罹患 2 型糖尿病（T2DM）风险之间的关系，但大多数研究都是横断面研究，因此很难找到直接的相关性。因此，本研究旨在分析纵向研究的数据，以确定独居是否会增加罹患 T2DM 的风险：方法：我们在 PubMed、Cochrane 和 Embase 数据库中进行了全面检索，以确定研究独居与 T2DM 风险之间关系的研究。检索涵盖了 2023 年 9 月之前发表的研究。汇总分析采用了反方差随机效应模型，包括调整后的危险比（HRs）及其相应的 95% 置信区间（CIs）：荟萃分析共包括 8 项研究，其中包括 5 项前瞻性队列研究和 3 项回顾性队列研究。研究对象包括 11,686,677 名无 T2DM 患者，其中 54.3% 为女性。在这些人群中，有 396,368 人患上了 T2DM。为考虑异质性，采用了随机效应模型。总体而言，汇总数据显示，与与他人同住相比，独居与 T2DM 风险增加之间存在显著关联（HR 1.24，95% CI 1.06-1.46）。亚组分析表明，无论是男性（HR 1.28，95% CI 0.93-1.76）还是女性（HR 1.06，95% CI 0.84-1.33），无论是前瞻性队列研究（HR 1.26，95% CI 0.91-1.74）还是回顾性队列研究（HR 1.26，95% CI 0.91-1.74），这一风险均无统计学意义：结论：与非独居者相比，独居者患糖尿病的风险明显更高。结论：与非独居者相比，独居者罹患糖尿病的风险明显更高，但不同性别和不同研究类型之间的风险差异并不明显。今后有必要进一步开展高质量的研究，以阐明这种因果关系。
Living alone increases the risk of developing type 2 diabetes mellitus: A systematic review and meta-analysis based on longitudinal studies
Background
Living alone is a prevalent psychological issue that has been found to have significant implications for lifestyle and health status. While considerable research has been conducted to explore the relationship between living alone and the risk of developing type 2 diabetes mellitus (T2DM), the majority of studies have been cross-sectional, leaving direct correlations elusive. Therefore, this study aims to analyze data from longitudinal studies to determine whether living alone increases the risk of T2DM.
Methods
A comprehensive search was conducted in the PubMed, Cochrane, and Embase databases to identify studies examining the association between living alone and T2DM risk. The search encompassed studies published until September 2023. Pooled analysis utilized the random-effects model with inverse variance and included adjusted hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs).
Results
The meta-analysis comprised a total of 8 studies, which consisted of 5 prospective cohort studies and 3 retrospective cohort studies. The total population under consideration included 11,686,677 individuals without T2DM, of whom 54.3% were female. Among this population, 396,368 individuals developed T2DM. To account for heterogeneity, a random-effects model was employed. Overall, the pooled data demonstrated a significant association between living alone and an increased risk of T2DM when compared to living with others (HR 1.24, 95% CI 1.06–1.46). Subgroup analysis revealed that this risk was not statistically significant for either males (HR 1.28, 95% CI 0.93–1.76) or females (HR 1.06, 95% CI 0.84–1.33), nor in prospective cohort studies (HR 1.26, 95% CI 0.91–1.74) or retrospective cohort studies (HR 1.26, 95% CI 0.91–1.74).
Conclusion
Individuals living alone faced a significantly higher risk of developing diabetes compared to those who did not live alone. However, no significant difference in this risk was observed between genders and study types. Further high-quality studies are necessary in the future to elucidate this causal association.
期刊介绍：
The journal publishes original research articles and high quality reviews in the fields of clinical care, diabetes education, nutrition, health services, psychosocial research and epidemiology and other areas as far as is relevant for diabetology in a primary-care setting. The purpose of the journal is to encourage interdisciplinary research and discussion between all those who are involved in primary diabetes care on an international level. The Journal also publishes news and articles concerning the policies and activities of Primary Care Diabetes Europe and reflects the society''s aim of improving the care for people with diabetes mellitus within the primary-care setting.
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