杜兴氏肌肉萎缩症与胰岛素抵抗的相互作用

IF 4.9 2区医学 Q1 PHYSIOLOGY

Exercise and Sport Sciences Reviews Pub Date : 2024-01-01 Epub Date: 2023-10-05 DOI:10.1249/JES.0000000000000328

Swathy Krishna, John C Quindry, Rudy J Valentine, Joshua T Selsby

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引用次数: 0

摘要

杜兴氏肌营养不良症（DMD）是由功能性肌营养不良蛋白缺乏引起的一种致命的进行性肌肉疾病，常伴有代谢失调。在此，我们探讨了在肥胖和胰岛素抵抗的背景下肌营养不良的生理后果。我们假设，肌营养不良会增加胰岛素抵抗的频率，而胰岛素抵抗会加剧肌营养不良引起的肌肉病理变化。

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The Interaction of Duchenne Muscular Dystrophy and Insulin Resistance.

Duchenne muscular dystrophy (DMD), caused by deficiency of functional dystrophin protein, is a fatal, progressive muscle disease that frequently includes metabolic dysregulation. Herein, we explore the physiologic consequences of dystrophin deficiency within the context of obesity and insulin resistance. We hypothesized that dystrophin deficiency increases the frequency of insulin resistance, and insulin resistance potentiates muscle pathology caused by dystrophin deficiency.

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来源期刊

Exercise and Sport Sciences Reviews 社会科学-生理学

CiteScore

10.70

自引率

1.80%

发文量

期刊介绍： Exercise and Sport Sciences Reviews made the transition from an annual hardcover series book to a quarterly journal in January 2000. The mission of this American College of Sports Medicine publication is to provide premier quarterly reviews of the most contemporary scientific, medical, and research-based topics emerging in the field of sports medicine and exercise science. The publication strives to provide the most relevant, topical information to students, professors, clinicians, scientists, and professionals for practical and research applications.