Xiaohong Qin MD, Jiao Sun PhD, Meiling Liu MD, Lianjie Zhang MD, Qing Yin MD, Si Chen MD
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The risk of bias in individual studies was assessed using the Cochrane Collaboration tool, and the certainty of evidence was assessed using the five GRADE criteria. Statistical analysis was performed using the RevMan 5.3 software, and information that could not be meta-analysed was reviewed in the form of a literature summary.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Eleven papers met the inclusion criteria with a combined sample size of 1070 cases, including 532 cases in the trial group and 538 cases in the control group. Four papers reported the effect of ONS on grip strength and included very low-quality evidence supporting no effect of ONS on grip strength. Ten studies reported the effect of ONS on body weight and body mass index (BMI) and included very low-quality evidence supporting a positive ONS on weight and BMI changes. Meta-analysis showed a significant reduction in weight loss (12–15 weeks) and BMI loss (12–15 weeks) in patients with colorectal cancer in the ONS group. The effect of ONS on the prevalence of sarcopenia after hospital discharge was reported in two studies, and meta-analysis showed a significant reduction in the prevalence of postoperative sarcopenia in colorectal cancer patients in the ONS group, but the quality of evidence was low.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>This study showed that the use of ONS in patients undergoing surgery for colorectal cancer improved patient weight loss and BMI reduction and reduced the prevalence of postoperative sarcopenia but did not improve patient grip strength. The quality of evidence for inclusion in the article was low or very low, and further studies are needed to provide better evidence.</p>\n </section>\n </div>","PeriodicalId":14223,"journal":{"name":"International Journal of Nursing Practice","volume":"30 3","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The effects of oral nutritional supplements interventions on nutritional status in patients undergoing colorectal cancer surgery: A systematic review\",\"authors\":\"Xiaohong Qin MD, Jiao Sun PhD, Meiling Liu MD, Lianjie Zhang MD, Qing Yin MD, Si Chen MD\",\"doi\":\"10.1111/ijn.13226\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>The high incidence of malnutrition in patients undergoing colorectal cancer surgery can lead to unplanned weight loss, sarcopenia and reduced grip strength to the extent that it can seriously affect the prognosis of colorectal cancer patients.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>This study investigated the effect of oral nutritional supplements (ONS) on the prevalence of grip strength, unplanned weight loss and sarcopenia in patients undergoing colorectal cancer surgery.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>We systematically searched randomized controlled studies from CINAHL, PubMed, Embase, Cochrane and Web of Science and three Chinese databases (CNKI, Wan-Fang database, VIP database) from database creation to September 2023. The risk of bias in individual studies was assessed using the Cochrane Collaboration tool, and the certainty of evidence was assessed using the five GRADE criteria. Statistical analysis was performed using the RevMan 5.3 software, and information that could not be meta-analysed was reviewed in the form of a literature summary.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Eleven papers met the inclusion criteria with a combined sample size of 1070 cases, including 532 cases in the trial group and 538 cases in the control group. Four papers reported the effect of ONS on grip strength and included very low-quality evidence supporting no effect of ONS on grip strength. Ten studies reported the effect of ONS on body weight and body mass index (BMI) and included very low-quality evidence supporting a positive ONS on weight and BMI changes. 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引用次数: 0
摘要
背景：接受结直肠癌手术的患者营养不良的发生率很高，可导致计划外体重减轻、肌肉疏松症和握力减弱，严重影响结直肠癌患者的预后：本研究探讨了口服营养补充剂（ONS）对结直肠癌手术患者握力、计划外体重减轻和肌肉疏松症发生率的影响：我们系统地检索了 CINAHL、PubMed、Embase、Cochrane 和 Web of Science 以及三个中文数据库（CNKI、万方数据库、VIP 数据库）中自数据库创建至 2023 年 9 月的随机对照研究。使用 Cochrane 协作工具评估了各研究的偏倚风险，并使用 GRADE 五项标准评估了证据的确定性。统计分析使用 RevMan 5.3 软件进行，无法进行荟萃分析的信息则以文献摘要的形式进行回顾：有 11 篇论文符合纳入标准，样本量共计 1070 例，其中试验组 532 例，对照组 538 例。四篇论文报告了 ONS 对握力的影响，其中包括支持 ONS 对握力无影响的极低质量证据。十项研究报告了 ONS 对体重和体重指数（BMI）的影响，其中质量很低的证据支持 ONS 对体重和体重指数的变化有积极影响。Meta 分析表明，ONS 组结直肠癌患者的体重下降（12-15 周）和体重指数下降（12-15 周）显著减少。有两项研究报告了 ONS 对出院后肌少症发生率的影响，荟萃分析显示 ONS 组结直肠癌患者术后肌少症发生率明显降低，但证据质量较低：本研究表明，在接受结直肠癌手术的患者中使用 ONS 可改善患者的体重减轻和体重指数降低情况，减少术后肌少症的发生率，但并不能改善患者的握力。纳入文章的证据质量较低或很低，需要进一步研究以提供更好的证据。
The effects of oral nutritional supplements interventions on nutritional status in patients undergoing colorectal cancer surgery: A systematic review
Background
The high incidence of malnutrition in patients undergoing colorectal cancer surgery can lead to unplanned weight loss, sarcopenia and reduced grip strength to the extent that it can seriously affect the prognosis of colorectal cancer patients.
Objective
This study investigated the effect of oral nutritional supplements (ONS) on the prevalence of grip strength, unplanned weight loss and sarcopenia in patients undergoing colorectal cancer surgery.
Methods
We systematically searched randomized controlled studies from CINAHL, PubMed, Embase, Cochrane and Web of Science and three Chinese databases (CNKI, Wan-Fang database, VIP database) from database creation to September 2023. The risk of bias in individual studies was assessed using the Cochrane Collaboration tool, and the certainty of evidence was assessed using the five GRADE criteria. Statistical analysis was performed using the RevMan 5.3 software, and information that could not be meta-analysed was reviewed in the form of a literature summary.
Results
Eleven papers met the inclusion criteria with a combined sample size of 1070 cases, including 532 cases in the trial group and 538 cases in the control group. Four papers reported the effect of ONS on grip strength and included very low-quality evidence supporting no effect of ONS on grip strength. Ten studies reported the effect of ONS on body weight and body mass index (BMI) and included very low-quality evidence supporting a positive ONS on weight and BMI changes. Meta-analysis showed a significant reduction in weight loss (12–15 weeks) and BMI loss (12–15 weeks) in patients with colorectal cancer in the ONS group. The effect of ONS on the prevalence of sarcopenia after hospital discharge was reported in two studies, and meta-analysis showed a significant reduction in the prevalence of postoperative sarcopenia in colorectal cancer patients in the ONS group, but the quality of evidence was low.
Conclusions
This study showed that the use of ONS in patients undergoing surgery for colorectal cancer improved patient weight loss and BMI reduction and reduced the prevalence of postoperative sarcopenia but did not improve patient grip strength. The quality of evidence for inclusion in the article was low or very low, and further studies are needed to provide better evidence.
期刊介绍：
International Journal of Nursing Practice is a fully refereed journal that publishes original scholarly work that advances the international understanding and development of nursing, both as a profession and as an academic discipline. The Journal focuses on research papers and professional discussion papers that have a sound scientific, theoretical or philosophical base. Preference is given to high-quality papers written in a way that renders them accessible to a wide audience without compromising quality. The primary criteria for acceptance are excellence, relevance and clarity. All articles are peer-reviewed by at least two researchers expert in the field of the submitted paper.
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