塞来昔布对 12-O- 十四碳酰樟脑-13-乙酸酯诱导的小鼠皮肤炎症、过度增殖和增生反应的潜在抑制作用。

IF 1.6 4区 医学 Q3 OPHTHALMOLOGY
Cutaneous and Ocular Toxicology Pub Date : 2024-03-01 Epub Date: 2024-01-01 DOI:10.1080/15569527.2023.2295843
Shakilur Rahman, Rizwanul Haque, Sheikh Raisuddin
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引用次数: 0

摘要

目的:皮肤暴露于有害物质会导致以炎症、细胞增殖和增生反应增加为特征的皮肤损伤。研究表明,这些损伤破坏了皮肤的完整性,导致各种皮肤疾病,如特应性皮炎、湿疹、牛皮癣和非黑素瘤皮肤癌的发生。塞来昔布是一种环氧化酶 2(COX-2)抑制剂,可有效治疗多种炎症性疾病。然而,它在皮肤问题治疗中的重要性仍未得到充分重视:方法:我们测试了局部使用塞来昔布对瑞士白化小鼠由光滑酯 12-O-十四碳酰樟脑酚-13-乙酸酯(TPA)诱导的皮肤炎症、细胞增殖和增生的影响:结果:塞来昔布(5 μmol 和 10 μmol)显著减少了 TPA(10 nmol)诱导的前列腺素 E2(PGE2)产生、水肿形成、髓过氧化物酶(MPO)活性以及肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)和白细胞介素-6(IL-6)等促炎细胞因子的水平。它还显著降低了鸟氨酸脱羧酶(ODC)活性和 DNA 中[3H]-胸苷的结合。此外,表皮厚度、表皮细胞层数量、中性粒细胞浸润、细胞间水肿和血管扩张等组织结构异常也有明显改善:我们的研究结果表明,外用塞来昔布可减轻皮肤损伤引起的炎症、过度增殖和增生,这表明塞来昔布可能被证明是治疗特应性皮炎、湿疹和银屑病等皮肤损伤和相关疾病以及非黑色素瘤癌症的一种有价值的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Potential inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced inflammation, hyperproliferation, and hyperplasiogenic responses by celecoxib in mouse skin.

Purpose: Skin exposure to noxious agents leads to cutaneous lesion marked by an increase in inflammation, cellular proliferation, and hyperplasiogenic reactions. Studies have demonstrated that these damages breach the skin integrity resulting in the aetiology of various cutaneous disorders like atopic dermatitis, eczema, psoriasis, and development of non-melanoma skin cancer. Celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, is an effective treatment for a variety of inflammatory diseases. Its importance in the therapy of skin problems, however, remains under appreciated.

Methods: We tested efficacy of topically applied celecoxib in mitigating skin inflammation, cellular proliferation, and hyperplasia induced by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) in Swiss albino mice.

Results: Celecoxib (5 and 10 μmol) markedly reduced TPA (10 nmol) induced prostaglandin E2 (PGE2) production, oedema formation, myeloperoxidase (MPO) activity, and levels of pro-inflammatory cytokines such as tumour necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6). It also resulted in a considerable decrease in ornithine decarboxylase (ODC) activity and the incorporation of [3H]-thymidine into DNA. In addition, there was a significant reduction in histoarchitectural abnormalities such as epidermal thickness, number of epidermal cell layers, neutrophil infiltration, intercellular oedema, and vasodilation.

Conclusion: Our results demonstrate that topical celecoxib can reduce the inflammation, hyperproliferation, and hyperplasiogenic events of skin insults suggesting that it may prove to be a valuable management option for cutaneous lesion and associated illnesses such as atopic dermatitis, eczema, and psoriasis, as well as the emergence of non-melanoma cancer.

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来源期刊
CiteScore
3.30
自引率
6.20%
发文量
40
审稿时长
1 months
期刊介绍: Cutaneous and Ocular Toxicology is an international, peer-reviewed journal that covers all types of harm to cutaneous and ocular systems. Areas of particular interest include pharmaceutical and medical products; consumer, personal care, and household products; and issues in environmental and occupational exposures. In addition to original research papers, reviews and short communications are invited, as well as concise, relevant, and critical reviews of topics of contemporary significance.
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