彼得伯勒公共卫生 COVID-19 快速抗原检测自我报告工具的实用性:对 COVID-19 监测的影响。

Erin Smith, Carolyn Pigeau, Jamal Ahmadian-Yazdi, Mohamed Kharbouch, Jane Hoffmeyer, Thomas Piggott
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引用次数: 0

摘要

背景:由于冠状病毒病 2019(COVID-19)大流行,有必要采用新的检测策略,包括使用快速抗原检测(RAT)。快速抗原检测仪在公众中的广泛使用促使彼得伯勒公共卫生部门启动了一项快速抗原检测仪自我报告工具试点,以评估其在 COVID-19 监测中的实用性。本研究的目的是利用 RAT 自我报告结果与 COVID-19 的其他指标之间的相关性来调查 RAT 的实用性:我们使用皮尔逊相关系数调查了 RAT 结果、PCR 检测结果和 nmN1N2 严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)基因废水水平(推断 COVID-19 水平)之间的关联。对 RAT 和聚合酶链反应(PCR)检测的阳性百分比和阳性计数进行了分析:PCR阳性率与废水呈弱相关(r=0.33,p=0.022),RAT阳性率与废水中 nmN1N2 水平也呈弱相关(r=0.33,p=0.002)。RAT 阳性率与 PCR 阳性率无显著相关性(r=-0.035,p=0.75)。RAT 阳性计数和 PCR 阳性计数呈中度相关(r=0.59,pp=0.864)或 PCR 阳性计数呈中度相关(r=0.004,p=0.971):我们的研究结果支持将 RAT 自我报告作为一种低成本、简单的 COVID-19 辅助监测工具,并表明由于阳性检测的报告偏差,在考虑阳性 RAT 的绝对数量而非阳性百分比时,其效用最大。这些结果有助于为地方公共卫生单位的 COVID-19 监测策略提供信息,并鼓励使用 RAT 自我报告工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Utility of the Peterborough Public Health COVID-19 rapid antigen test self-report tool: Implications for COVID-19 surveillance.

Background: The ongoing coronavirus disease 2019 (COVID-19) pandemic has necessitated novel testing strategies, including the use of rapid antigen tests (RATs). The widespread distribution of RATs to the public prompted Peterborough Public Health to launch a pilot RAT self-report tool to assess its utility in COVID-19 surveillance. The objective of this study is to investigate the utility of RAT using correlations between RAT self-report results and other indicators of COVID-19.

Methods: We investigated the association between RAT results, PCR test results and wastewater levels of nmN1N2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genes (to infer COVID-19 levels) using Pearson's correlation coefficient. Percent positivity and count of positive tests for RATs and polymerase chain reaction (PCR) tests were analyzed.

Results: The PCR percent positivity and wastewater were weakly correlated (r=0.33, p=0.022), as were RAT percent positivity and wastewater nmN1N2 levels (r=0.33, p=0.002). The RAT percent positivity and PCR percent positivity were not significantly correlated (r=-0.035, p=0.75). Count of positive RATs and count of positive PCR tests were moderately correlated (r=0.59, p<0.001). Wastewater nmN1N2 levels were not significantly correlated with either count of positive RATs (r=0.019, p=0.864) or count of positive PCR tests (r=0.004, p=0.971).

Conclusion: Our results support the use of RAT self-reporting as a low-cost simple adjunctive COVID-19 surveillance tool, and suggest that its utility is greatest when considering an absolute count of positive RATs rather than percent positivity due to reporting bias towards positive tests. These results can help inform COVID-19 surveillance strategies of local public health units and encourage the use of a RAT self-report tool.

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