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引用次数: 0
摘要
2021 年发布的世界卫生组织(WHO)第五次中枢神经系统(CNS)肿瘤分类中引入了大量变化,包括新的实体、对以前类别更清晰的分类、与临床表现更好的相关性以及术语的变化。除组织病理学外,基于分子特征的定义不断增加。在此,我们将重点介绍第五次中枢神经系统 WHO 分类的基本原则,并对胶质瘤、神经胶质细胞瘤、神经元瘤、脉络丛瘤、胚胎瘤、松果体瘤以及脑膜瘤进行更详细的讨论。我们特别关注新的实体以及标准和名称的改变。我们的主要目标是介绍 "经典 "病理学方面的内容,但也简要讨论了不可分割的分子病理学特征,但仅限于理解所需的程度。我们的目标是为神经肿瘤学和神经病理学从业者提供一个了解中枢神经系统肿瘤现代分类的指南。
[Classical pathology and basic concepts of the current WHO classification (5th edition) of central nervous system tumors].
Considerable changes were introduced into the 5th World Health Organization (WHO) classification of central nervous system (CNS) tumors, published in 2021, including new entities, a clearer classification of previous categories, correlating better with clinical behavior and changes in nomenclature. The number of definitions based on molecular features in addition to histopathology continued to increase. Here, we highlight the basic principles of the 5th CNS WHO classification and discuss glial, glioneuronal, neuronal, choroid plexus, embryonal and pineal tumors, as well as meningiomas in more details. We pay special attention to new entities as well as altered criteria and designations. Our primary goal is to present the "classical" pathological aspects, but the inseparable molecular pathological features are also briefly discussed, to the absolutely necessary extent for comprehension. We aim to provide a guideline to understand the modern classification of CNS tumors for practitioners of neuro-oncology and neuropathology.