Daniela Gompelmann, Pavla Sarova, Berta Mosleh, Anastasia Papaporfyriou, Felicitas Oberndorfer, Marco Idzko, Mir Alireza Hoda
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PD-L1 assessment in lung cancer biopsies-pitfalls and limitations.
The programmed cell death-ligand 1 (PD-L1) protein expression on tumor cells predicts the efficacy of immunotherapy in patients with non-small cell lung cancer. However, the assessment of PD-L1 expression on tumor cells has limited power for selecting patients for immunotherapy due to intra-tumoral heterogeneity and inter-tumoral heterogeneity of PD-L1 expression, the inter-observer variability in scoring PD-L1 staining, and reproducibility. These difficulties and pitfalls in interpreting the PD-L1 assessment are discussed in detail in this review.
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