J Rivadeneyra-Posadas, L Simón-Vicente, D Castillo-Alvira, J Raya-González, M Soto-Celix, A Rodríguez-Fernández, A García-Bustillo, M Saiz-Rodríguez, F Vázquez-Sánchez, L Aguado-Garcia, G Gámez Leyva-Hernández, E Cubo
{"title":"如何估计亨廷顿氏病患者的身体成分。一项使用多频率生物阻抗的横断面观察研究。","authors":"J Rivadeneyra-Posadas, L Simón-Vicente, D Castillo-Alvira, J Raya-González, M Soto-Celix, A Rodríguez-Fernández, A García-Bustillo, M Saiz-Rodríguez, F Vázquez-Sánchez, L Aguado-Garcia, G Gámez Leyva-Hernández, E Cubo","doi":"10.33588/rn.7801.2023224","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Huntington´s disease (HD) is a rare neurodegenerative disorder. Reliable information about nutritional status, especially body composition from individuals with HD is critical for clinical care and research. The ease of application and portability of multiple frequencies bioelectrical impedance analysis (mfBIA) make it an attractive tool for measuring body composition, but its accuracy in HD is unknown.</p><p><strong>Aim: </strong>To evaluate the accuracy of mfBIA vs. Dual X-ray absorptiometry (DEXA) in HD.</p><p><strong>Patients and methods: </strong>Cross-sectional, observational, and single-center study. HD severity was measured using motor subscale of the unified Huntington´s disease rating scale (m-UHDRS) and the total functional capacity (TFC). Body composition was measured in terms of fat-free mass (FFM), fat mass (FM), fat-free mass index (FFMI), and fat mass index (FMI). Using Bland-Altman plots, we analyzed reliability between DEXA and mfBIA using the Intraclass Correlation Coefficient with 95% confidence intervals (CI) and bias estimates for all.</p><p><strong>Results: </strong>We included 16 patients with HD, 7 men, and 9 women, median age of 58.5 (32;68) years, TFC: 10 (3;13), and m-UHDRS: 31 (7;85). The reliability between mfBIA and DEXA were high for FFMI in men: 0.88 (95% CI 0.17-0.98), and women: 0.90 (95% CI 0.61- 0.98); for FMI, men: 0.97 (95% CI 0.83-0.99), and women: 0.91 (95% CI 0.68-0.98). Compared to DEXA, mfBIA slightly overestimated FFM, FM, FMI and FFMI in men and underestimated FFMI in women.</p><p><strong>Conclusions: </strong>mfBIA is an easy-to-use, safe, non-invasive, accurate method for measuring body composition and nutritional status in patients with mild-moderate HD.</p>","PeriodicalId":21281,"journal":{"name":"Revista de neurologia","volume":"78 1","pages":"17-25"},"PeriodicalIF":0.8000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11064940/pdf/","citationCount":"0","resultStr":"{\"title\":\"How to estimate body composition in Huntington's disease. 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Using Bland-Altman plots, we analyzed reliability between DEXA and mfBIA using the Intraclass Correlation Coefficient with 95% confidence intervals (CI) and bias estimates for all.</p><p><strong>Results: </strong>We included 16 patients with HD, 7 men, and 9 women, median age of 58.5 (32;68) years, TFC: 10 (3;13), and m-UHDRS: 31 (7;85). The reliability between mfBIA and DEXA were high for FFMI in men: 0.88 (95% CI 0.17-0.98), and women: 0.90 (95% CI 0.61- 0.98); for FMI, men: 0.97 (95% CI 0.83-0.99), and women: 0.91 (95% CI 0.68-0.98). 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引用次数: 0
摘要
简介亨廷顿氏病（Huntington´s disease，HD）是一种罕见的神经退行性疾病。有关 HD 患者营养状况，尤其是身体成分的可靠信息对临床治疗和研究至关重要。多频率生物电阻抗分析法（mfBIA）应用简便、携带方便，是测量身体成分的一种有吸引力的工具，但其在HD中的准确性尚不清楚。目的：评估多频率生物电阻抗分析法与双X射线吸收测量法（DEXA）在HD中的准确性：横断面、观察性、单中心研究。采用亨廷顿统一评定量表（m-UHDRS）的运动分量表和总功能能力（TFC）测量HD的严重程度。身体成分以无脂质量（FFM）、脂肪质量（FM）、无脂质量指数（FFMI）和脂肪质量指数（FMI）进行测量。使用Bland-Altman图，我们使用类内相关系数（Intraclass Correlation Coefficient）和95%置信区间（CI）分析了DEXA和mfBIA之间的可靠性，并对所有数据进行了偏差估计：我们共纳入了 16 名 HD 患者，其中男性 7 名，女性 9 名，中位年龄为 58.5 (32;68) 岁，TFC：10 (3;13) ，m-UHDRS：31 (7;85)。mfBIA 和 DEXA 之间的可靠性很高，男性的 FFMI 为 0.88 (95% CI 0.17-0.98)，女性为 0.90 (95% CI 0.61-0.98)；男性的 FMI 为 0.97 (95% CI 0.83-0.99)，女性为 0.91 (95% CI 0.68-0.98)。与 DEXA 相比，mfBIA 稍微高估了男性的 FFM、FM、FMI 和 FFMI，低估了女性的 FFMI。结论：mfBIA 是一种易于使用、安全、无创、准确的方法，可用于测量轻度-中度 HD 患者的身体成分和营养状况。
How to estimate body composition in Huntington's disease. A cross-sectional, observational study using multiple frequencies bioimpedance.
Introduction: Huntington´s disease (HD) is a rare neurodegenerative disorder. Reliable information about nutritional status, especially body composition from individuals with HD is critical for clinical care and research. The ease of application and portability of multiple frequencies bioelectrical impedance analysis (mfBIA) make it an attractive tool for measuring body composition, but its accuracy in HD is unknown.
Aim: To evaluate the accuracy of mfBIA vs. Dual X-ray absorptiometry (DEXA) in HD.
Patients and methods: Cross-sectional, observational, and single-center study. HD severity was measured using motor subscale of the unified Huntington´s disease rating scale (m-UHDRS) and the total functional capacity (TFC). Body composition was measured in terms of fat-free mass (FFM), fat mass (FM), fat-free mass index (FFMI), and fat mass index (FMI). Using Bland-Altman plots, we analyzed reliability between DEXA and mfBIA using the Intraclass Correlation Coefficient with 95% confidence intervals (CI) and bias estimates for all.
Results: We included 16 patients with HD, 7 men, and 9 women, median age of 58.5 (32;68) years, TFC: 10 (3;13), and m-UHDRS: 31 (7;85). The reliability between mfBIA and DEXA were high for FFMI in men: 0.88 (95% CI 0.17-0.98), and women: 0.90 (95% CI 0.61- 0.98); for FMI, men: 0.97 (95% CI 0.83-0.99), and women: 0.91 (95% CI 0.68-0.98). Compared to DEXA, mfBIA slightly overestimated FFM, FM, FMI and FFMI in men and underestimated FFMI in women.
Conclusions: mfBIA is an easy-to-use, safe, non-invasive, accurate method for measuring body composition and nutritional status in patients with mild-moderate HD.
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