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引用次数: 0
摘要
成功占据一个特定的生态位需要定殖细菌与生物和非生物环境(包括其他常驻微生物)进行广泛的互动。为此,细菌进化出了一系列蛋白质分泌机器,迄今已发现 11 种此类系统。芽孢杆菌利用 VIIb 型分泌系统(T7SSb)分泌一系列蛋白质底物,包括针对密切相关菌株的抗菌毒素。本综述涉及 T7SSb 的组成和分泌机制、这些系统的底物及其在革兰氏阳性菌中的作用,重点是细菌间的竞争。
Interbacterial competition mediated by the type VIIb secretion system.
Successful occupancy of a given niche requires the colonising bacteria to interact extensively with the biotic and abiotic environment, including other resident microbes. Bacteria have evolved a range of protein secretion machines for this purpose with eleven such systems identified to date. The type VIIb secretion system (T7SSb) is utilised by Bacillota to secrete a range of protein substrates, including antibacterial toxins targeting closely related strains, and the system as a whole has been implicated in a range of activities such as iron acquisition, intercellular signalling, host colonisation and virulence. This review covers the components and secretion mechanism of the T7SSb, the substrates of these systems and their roles in Gram-positive bacteria, with a focus on interbacterial competition.
期刊介绍:
We publish high-quality original research on bacteria, fungi, protists, archaea, algae, parasites and other microscopic life forms.
Topics include but are not limited to:
Antimicrobials and antimicrobial resistance
Bacteriology and parasitology
Biochemistry and biophysics
Biofilms and biological systems
Biotechnology and bioremediation
Cell biology and signalling
Chemical biology
Cross-disciplinary work
Ecology and environmental microbiology
Food microbiology
Genetics
Host–microbe interactions
Microbial methods and techniques
Microscopy and imaging
Omics, including genomics, proteomics and metabolomics
Physiology and metabolism
Systems biology and synthetic biology
The microbiome.