嗜酸性淋巴肉芽肿低剂量放疗的有效性和安全性

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-01

Yudi You, Haiying Zhou, Xiulan Liu, Wei Zhang, Yuanzhe Xiao, Yabing Dong, Zhinan Liang, Chunmei Ni, Yujin Su

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引用次数: 0

摘要

目的：探讨低剂量放射疗法治疗嗜酸性淋巴肉芽肿的疗效和安全性：探讨低剂量放疗治疗嗜酸性淋巴肉芽肿的有效性和安全性：本研究共纳入20例确诊为嗜酸性淋巴肉芽肿的患者。所有患者均接受了低剂量三维适形调强放射治疗。我们分析了病灶的控制情况以及与放疗相关的不良反应：结果：低剂量放疗治疗嗜酸性淋巴肉芽肿的总体有效率为90%。放疗引起的I级和II级不良反应发生率分别为70%和30%。在中位 23.6 个月的随访期间，所有患者的病灶均在放疗靶区内得到控制。放疗后，4 名患者偶感瘙痒，1 名患者 3 年后在靶区外复发。随访期间未发现与放疗相关的长期严重不良反应：结论：低剂量放疗对嗜酸性淋巴肉芽肿有明显的治疗效果，且不良反应可接受。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Effectiveness and Safety of Low-Dose Radiotherapy in Eosinophilic Lymphoid Granuloma.

Objective: To investigate the efficacy and safety of low-dose radiotherapy in treating eosinophilic lymphoid granuloma.

Method: This study included a total of 20 patients diagnosed with eosinophilic lymphoid granuloma. All patients underwent low-dose three-dimensional conformal intensity-modulated radiotherapy for their lesions. We analyzed the control status of the lesions and any adverse reactions related to radiotherapy.

Results: The overall effectiveness of low-dose radiotherapy in treating eosinophilic lymphoid granuloma was 90%. The incidence of grade I and grade II adverse reactions induced by radiotherapy was 70% and 30%, respectively. Over a median follow-up period of 23.6 months, all patients showed controlled lesions within the target delineation of radiotherapy. After radiotherapy, four patients experienced occasional pruritus, and one patient had a recurrence outside the target area three years later. No long-term severe adverse reactions related to radiotherapy were observed during the follow-up period.

Conclusions: Low-dose radiotherapy demonstrates an apparent therapeutic effect on eosinophilic lymphoid granuloma with acceptable adverse reactions.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.