[金属-二膦]催化的 β-氨基 β-取代丙烯酸酯的不对称加氢反应：实用文献综述
IF 3.1
3区 化学
Q2 CHEMISTRY, APPLIED
引用次数: 0
摘要
本文综述了过渡金属络合物催化典型的 β-氨基 β-（甲基或苯基）丙烯酸酯（及其近似衍生物）不对称氢化成相应的对映体丰富的 β-氨基丙酸酯的过程。文献报告（包括专利）介绍了高效的对映纯 P,P-配体催化系统（其中 P,P-配体为顺式螯合二膦），这些报告在其公开的测试条件下对每种底物的对映选择性进行了并列。这样的列表清楚地揭示了它们的相对性能，并为今后的开发提供了实用指南。本文章由计算机程序翻译，如有差异，请以英文原文为准。
![[Metal–Diphosphine]-Catalyzed Asymmetric Hydrogenation of β-Amido β-Substituted Acrylates: A Practical Literature Overview](https://img.booksci.cn/booksciimg/2023-12/20231221103545763878.png)
![[Metal–Diphosphine]-Catalyzed Asymmetric Hydrogenation of β-Amido β-Substituted Acrylates: A Practical Literature Overview](https://img.booksci.cn/booksciimg/2023-12/96286597811734378873.jpg)
[Metal–Diphosphine]-Catalyzed Asymmetric Hydrogenation of β-Amido β-Substituted Acrylates: A Practical Literature Overview
Transition-metal-complex-catalyzed asymmetric hydrogenation of archetypal β-amido β-(methyl or phenyl)acrylates (and close derivatives) into the corresponding enantioenriched β-amido propionates is reviewed. The literature reports (including patents) on efficient enantiopure P,P-ligand-enabled catalytic systems─wherein the P,P-ligand is a cis-chelating diphosphine─are juxtaposed under their disclosed testing conditions per substrate along with the scored enantioselectivity. Such a listing clearly reveals their relative performance and constitutes a practical guide to inspire future development.
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来源期刊
CiteScore
6.90
自引率
14.70%
发文量
251
审稿时长
2 months
期刊介绍：
The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.
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