细胞静止将 argonaute-2 送到转座子上

IF 81.3 1区生物学 Q1 CELL BIOLOGY

Nature Reviews Molecular Cell Biology Pub Date : 2023-12-19 DOI:10.1038/s41580-023-00696-7

Eytan Zlotorynski

引用次数: 0

摘要

细胞静止可抑制 mTOR 信号，并使 AGO2 定位到细胞核，在细胞核中直接裂解逆转录转座子的 RNA，从而抑制逆转录转座子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cell quiescence sends argonaute-2 to transposons

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Cell quiescence sends argonaute-2 to transposons

Cell quiescence dampens mTOR signalling and enables AGO2 localization to the nucleus, where it suppresses retrotransposons by directly cleaving their RNA.

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来源期刊

Nature Reviews Molecular Cell Biology 生物-细胞生物学

CiteScore

173.60

自引率

0.50%

发文量

118

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Molecular Cell Biology is a prestigious journal that aims to be the primary source of reviews and commentaries for the scientific communities it serves. The journal strives to publish articles that are authoritative, accessible, and enriched with easily understandable figures, tables, and other display items. The goal is to provide an unparalleled service to authors, referees, and readers, and the journal works diligently to maximize the usefulness and impact of each article. Nature Reviews Molecular Cell Biology publishes a variety of article types, including Reviews, Perspectives, Comments, and Research Highlights, all of which are relevant to molecular and cell biologists. The journal's broad scope ensures that the articles it publishes reach the widest possible audience.