{"title":"利用固体分散和泡腾崩解技术提高难溶性药物氟苯尼考的溶出率和口服生物利用度","authors":"Chao Li, Nanxin Li, Xingyu Chen, Xiaojuan Li, Chang Liu, Awn Abbas, Yueli Wang, Shuangcai Qi, Yifan Zhang, Dongbo Li, Wei Zhang, Gang Shu, Juchun Lin, Haohuan Li, Funeng Xu, Guangneng Peng, Hualin Fu","doi":"10.1080/03639045.2023.2295488","DOIUrl":null,"url":null,"abstract":"ObjectiveFlorfenicol(FF) is an excellent veterinary antibiotic, limited by poor solubility and poor bioavailability. Significance: Here in, we aimed to explore the applicability of fast disintegrat...","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Enhancement of dissolution rate and oral bioavailability of poorly soluble drug florfenicol by using solid dispersion and effervescent disintegration technology\",\"authors\":\"Chao Li, Nanxin Li, Xingyu Chen, Xiaojuan Li, Chang Liu, Awn Abbas, Yueli Wang, Shuangcai Qi, Yifan Zhang, Dongbo Li, Wei Zhang, Gang Shu, Juchun Lin, Haohuan Li, Funeng Xu, Guangneng Peng, Hualin Fu\",\"doi\":\"10.1080/03639045.2023.2295488\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"ObjectiveFlorfenicol(FF) is an excellent veterinary antibiotic, limited by poor solubility and poor bioavailability. Significance: Here in, we aimed to explore the applicability of fast disintegrat...\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2023-12-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/03639045.2023.2295488\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/03639045.2023.2295488","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
Enhancement of dissolution rate and oral bioavailability of poorly soluble drug florfenicol by using solid dispersion and effervescent disintegration technology
ObjectiveFlorfenicol(FF) is an excellent veterinary antibiotic, limited by poor solubility and poor bioavailability. Significance: Here in, we aimed to explore the applicability of fast disintegrat...
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