烟酰胺单核苷酸通过 SIRT1/NF-κB 途径调节巨噬细胞极化，从而减轻内毒素诱导的急性肺损伤

IF 3.9 3区医学 Q1 MEDICAL LABORATORY TECHNOLOGY

Pharmaceutical Biology Pub Date : 2023-12-15 DOI:10.1080/13880209.2023.2292256

Simeng He, Xianhong Jiang, Jing Yang, Ya Wu, Jia Shi, Xiaoyang Wu, Shihan Du, Yuan Zhang, Lirong Gong, Shuan Dong, Jianbo Yu

引用次数: 0

摘要

脓毒症诱发的急性肺损伤（ALI）是一种严重的疾病，有效的治疗方法有限；据报道，烟酰胺单核苷酸（NMN）具有抗炎活性。

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Nicotinamide mononucleotide alleviates endotoxin-induced acute lung injury by modulating macrophage polarization via the SIRT1/NF-κB pathway

Sepsis-induced acute lung injury (ALI) is a severe condition with limited effective therapeutics; nicotinamide mononucleotide (NMN) has been reported to exert anti-inflammatory activities.This stud...

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来源期刊

Pharmaceutical Biology 医学-药学

CiteScore

6.70

自引率

2.60%

发文量

191

审稿时长

1 months

期刊介绍： Pharmaceutical Biology will publish manuscripts describing the discovery, methods for discovery, description, analysis characterization, and production/isolation (including sources and surveys) of biologically-active chemicals or other substances, drugs, pharmaceutical products, or preparations utilized in systems of traditional medicine. Topics may generally encompass any facet of natural product research related to pharmaceutical biology. Papers dealing with agents or topics related to natural product drugs are also appropriate (e.g., semi-synthetic derivatives). Manuscripts will be published as reviews, perspectives, regular research articles, and short communications. The primary criteria for acceptance and publication are scientific rigor and potential to advance the field.