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引用次数: 0
摘要
突变对细胞过程的影响是截然不同的。它们主要产生于 DNA 复制错误或环境挑战诱发的损伤修复过程。累积突变是基因变异和进化的基础,同时也是癌症和衰老等退行性疾病的诱因。突变表型阐明了在恶性肿瘤中观察到的更高突变率。进化适应与细菌和真核生物系统类似,在不断变化的环境条件下通过突变体表型表现出来,突显了有利突变与其潜在有害后果之间的微妙平衡。利用酿酒酵母的遗传可操作性,可以对突变表型和类似人类癌症的基因组不稳定性有独特的见解。酵母模式生物中的创新报告检测方法能够检测各种基因组改变,有助于对突变体表型进行全面分析。尽管取得了重大进展,但我们对控制自发突变率和保持基因完整性的复杂机制的了解仍不全面。这篇综述概述了影响突变率的各种细胞途径,并探讨了突变基因的作用和突变衍生的表型,尤其是在恶性肿瘤细胞中普遍存在的表型。深入了解酵母和高等真核生物中的突变基因和抗突变基因的活动,为制定有效的癌症控制策略带来了希望。
Signification and Application of Mutator and Antimutator Phenotype-Induced Genetic Variations in Evolutionary Adaptation and Cancer Therapeutics
Mutations present a dichotomy in their implications for cellular processes. They primarily arise from DNA replication errors or damage repair processes induced by environmental challenges. Cumulative mutations underlie genetic variations and drive evolution, yet also contribute to degenerative diseases such as cancer and aging. The mutator phenotype elucidates the heightened mutation rates observed in malignant tumors. Evolutionary adaptation, analogous to bacterial and eukaryotic systems, manifests through mutator phenotypes during changing environmental conditions, highlighting the delicate balance between advantageous mutations and their potentially detrimental consequences. Leveraging the genetic tractability of Saccharomyces cerevisiae offers unique insights into mutator phenotypes and genome instability akin to human cancers. Innovative reporter assays in yeast model organisms enable the detection of diverse genome alterations, aiding a comprehensive analysis of mutator phenotypes. Despite significant advancements, our understanding of the intricate mechanisms governing spontaneous mutation rates and preserving genetic integrity remains incomplete. This review outlines various cellular pathways affecting mutation rates and explores the role of mutator genes and mutation-derived phenotypes, particularly prevalent in malignant tumor cells. An in-depth comprehension of mutator and antimutator activities in yeast and higher eukaryotes holds promise for effective cancer control strategies.
期刊介绍:
Publishes papers that deal with research on microorganisms, including archaea, bacteria, yeasts, fungi, microalgae, protozoa, and simple eukaryotic microorganisms. Topics considered for publication include Microbial Systematics, Evolutionary Microbiology, Microbial Ecology, Environmental Microbiology, Microbial Genetics, Genomics, Molecular Biology, Microbial Physiology, Biochemistry, Microbial Pathogenesis, Host-Microbe Interaction, Systems Microbiology, Synthetic Microbiology, Bioinformatics and Virology. Manuscripts dealing with simple identification of microorganism(s), cloning of a known gene and its expression in a microbial host, and clinical statistics will not be considered for publication by JM.