花生四烯酸水平与脑出血并发严重运动麻痹后的早期运动恢复有关

IF 3
Takeo Sato , Motohiro Okumura , Junichiro Takahashi , Tatsushi Kokubu , Maki Tanabe , Asako Onda , Teppei Komatsu , Kenichi Sakuta , Kenichiro Sakai , Tadashi Umehara , Hidetaka Mitsumura , Masato Matsushima , Yasuyuki Iguchi
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引用次数: 0

摘要

背景:据报道,低花生四烯酸(AA)水平与脑内出血(ICH)的不利预后有关:我们旨在明确血清 AA 水平是否与住院早期严重运动麻痹的良好恢复有关:方法:从 2012 年 10 月至 2021 年 12 月期间的连续 ICH 患者中,纳入入院时上下肢美国国立卫生研究院卒中量表(NIHSS)评分总和为 4-8 分(重度运动麻痹)的患者。我们将入院后第 7 天上肢和下肢 NIHSS 评分之和为 0-3 分定义为重度运动麻痹早期恢复良好,将入院后第 7 天上肢和下肢 NIHSS 评分之和为 0-1 分定义为重度运动麻痹早期恢复良好。我们的目的是评估血清 AA 水平是否与严重运动麻痹的早期良好恢复有关:我们对 377 名连续 ICH 患者进行了筛查,其中包括 140 名重度运动麻痹患者(88 名(63%)男性,中位年龄 64 岁)。有 48 例(34%)重度运动麻痹患者痊愈。较高的 AA 水平(PR 1.243,95% CI 1.042 至 1.483,p = 0.016)与总体恢复良好以及上肢和下肢分别恢复良好独立相关(上肢:PR 1.319,95% CI 1.042 至 1.483,p = 0.016):PR 1.319,95% CI 1.101 至 1.580,p = 0.003;下肢:结论:较高的 AA 水平可能有助于 ICH 引起的严重运动性瘫痪患者在早期获得良好的运动恢复。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Arachidonic acid level is related to early motor recovery following intracerebral hemorrhage with severe motor paralysis

Background

Low arachidonic acid (AA) levels are reportedly associated with unfavorable outcomes in intracerebral hemorrhage (ICH).

Objective

We aimed to clarify whether serum AA levels might be associated with a good recovery from severe motor paralysis in the early stage of hospitalization.

Methods

From among consecutive ICH patients between October 2012 and December 2021, patients with a sum of upper and lower extremity National Institutes of Health stroke scale (NIHSS) scores of 4–8 at admission (severe motor paralysis) were included. We defined good early recovery from severe motor paralysis as a sum of upper and lower extremity NIHSS scores of 0–3 on day 7 after admission, and that of individual upper and lower extremities as NIHSS scores of 0–1 on day 7 after admission. We aimed to assess whether serum AA levels might be associated with good early recovery from severe motor paralysis.

Results

We screened 377 consecutive ICH patients, including 140 with severe motor paralysis (88 (63%) males, median age 64 years). Recovery from severe motor paralysis was seen in 48 (34%). Higher AA levels (PR 1.243, 95% CI 1.042 to 1.483, p = 0.016) were independently associated with good overall recovery, and good recovery of upper and lower extremities separately (upper extremity: PR 1.319, 95% CI 1.101 to 1.580, p = 0.003; lower extremity: PR 1.293, 95% CI 1.115 to 1.499, p = 0.001).

Conclusions

Higher AA levels may contribute to a good early motor recovery in patients with severe motor paralysis due to ICH.

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来源期刊
Prostaglandins, leukotrienes, and essential fatty acids
Prostaglandins, leukotrienes, and essential fatty acids Clinical Biochemistry, Endocrinology, Diabetes and Metabolism
CiteScore
5.30
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审稿时长
64 days
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