{"title":"南欧人口(巴斯克地区)的年龄和饮食习惯对红血球膜脂肪酸的影响","authors":"Gerard Marrugat , Ainara Cano , Javier Amézaga , Sara Arranz , Nieves Embade , Óscar Millet , Carla Ferreri , Itziar Tueros","doi":"10.1016/j.plefa.2023.102602","DOIUrl":null,"url":null,"abstract":"<div><p>The levels of blood eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are very variable and, in general, low in most of the world population. In this study, the effects of age, sex, COVID-19, and dietary habits on the lipid profile of the erythrocyte membranes were assessed in a sub-cohort of healthy population (<em>N</em> = 203) from a large cohort of individuals from the Basque Country, Spain, (AKRIBEA). Sex did not have an effect on RBC lipid profile. COVID-19 infected participants showed higher levels of DGLA. Oldest participants showed higher oleic acid, EPA and DHA levels. Arachidonic acid in RBC correlated positively with the intake of sunflower oil, butter, eggs, processed and red meat, whereas DHA and EPA correlated positively with oily and lean fish. Basque Country population showed lipid profiles similar to other high fish consuming countries, such as Italy and Japan. Baseline levels of the whole lipidomic profile of the RBC including SFA, MUFA and PUFA should be examined to obtain a better description of the health and nutritional status.</p></div>","PeriodicalId":94179,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"200 ","pages":"Article 102602"},"PeriodicalIF":3.0000,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0952327823000716/pdfft?md5=f41f9a4ec142773819ddbc92b153011f&pid=1-s2.0-S0952327823000716-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Effect of age and dietary habits on Red Blood Cell membrane fatty acids in a Southern Europe population (Basque Country)\",\"authors\":\"Gerard Marrugat , Ainara Cano , Javier Amézaga , Sara Arranz , Nieves Embade , Óscar Millet , Carla Ferreri , Itziar Tueros\",\"doi\":\"10.1016/j.plefa.2023.102602\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The levels of blood eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are very variable and, in general, low in most of the world population. In this study, the effects of age, sex, COVID-19, and dietary habits on the lipid profile of the erythrocyte membranes were assessed in a sub-cohort of healthy population (<em>N</em> = 203) from a large cohort of individuals from the Basque Country, Spain, (AKRIBEA). Sex did not have an effect on RBC lipid profile. COVID-19 infected participants showed higher levels of DGLA. Oldest participants showed higher oleic acid, EPA and DHA levels. Arachidonic acid in RBC correlated positively with the intake of sunflower oil, butter, eggs, processed and red meat, whereas DHA and EPA correlated positively with oily and lean fish. Basque Country population showed lipid profiles similar to other high fish consuming countries, such as Italy and Japan. Baseline levels of the whole lipidomic profile of the RBC including SFA, MUFA and PUFA should be examined to obtain a better description of the health and nutritional status.</p></div>\",\"PeriodicalId\":94179,\"journal\":{\"name\":\"Prostaglandins, leukotrienes, and essential fatty acids\",\"volume\":\"200 \",\"pages\":\"Article 102602\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2023-12-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0952327823000716/pdfft?md5=f41f9a4ec142773819ddbc92b153011f&pid=1-s2.0-S0952327823000716-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Prostaglandins, leukotrienes, and essential fatty acids\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0952327823000716\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins, leukotrienes, and essential fatty acids","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0952327823000716","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
血液中二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)的含量变化很大,而且在世界大多数人口中普遍偏低。在这项研究中,我们从西班牙巴斯克地区的一个大型队列(AKRIBEA)中抽取了一个健康人群子队列(203 人),评估了年龄、性别、COVID-19 和饮食习惯对红细胞膜脂质分布的影响。性别对红细胞脂质没有影响。COVID-19 感染者的 DGLA 水平较高。年龄最大的参与者的油酸、EPA 和 DHA 水平较高。红细胞中的花生四烯酸与葵花籽油、黄油、鸡蛋、加工肉类和红肉的摄入量呈正相关,而 DHA 和 EPA 与油鱼和瘦肉呈正相关。巴斯克地区人口的血脂状况与意大利和日本等其他鱼类消费量高的国家相似。为了更好地描述健康和营养状况,应该对包括 SFA、MUFA 和 PUFA 在内的整个红细胞脂质体概况的基线水平进行检查。
Effect of age and dietary habits on Red Blood Cell membrane fatty acids in a Southern Europe population (Basque Country)
The levels of blood eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are very variable and, in general, low in most of the world population. In this study, the effects of age, sex, COVID-19, and dietary habits on the lipid profile of the erythrocyte membranes were assessed in a sub-cohort of healthy population (N = 203) from a large cohort of individuals from the Basque Country, Spain, (AKRIBEA). Sex did not have an effect on RBC lipid profile. COVID-19 infected participants showed higher levels of DGLA. Oldest participants showed higher oleic acid, EPA and DHA levels. Arachidonic acid in RBC correlated positively with the intake of sunflower oil, butter, eggs, processed and red meat, whereas DHA and EPA correlated positively with oily and lean fish. Basque Country population showed lipid profiles similar to other high fish consuming countries, such as Italy and Japan. Baseline levels of the whole lipidomic profile of the RBC including SFA, MUFA and PUFA should be examined to obtain a better description of the health and nutritional status.