褪黑激素促进在三维脱细胞人睾丸基质上培养的人精原干细胞分化

IF 1.5 4区医学 Q3 UROLOGY & NEPHROLOGY

Urology Journal Pub Date : 2023-12-10 DOI:10.22037/uj.v20i.7846

Maryam Salem, Farnaz Khadivi, Narjes Feizollahi, Mahshad Khodarahmian, Mojtaba Saedi Marghmaleki, Shimal Ayub, Raziye Chegini, Zahra Bashiri, Yasaman Abbasi, Mohammad Naji, Mehdi Abbasi

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引用次数: 0

摘要

三维（3-Dimensional）培养系统支持细胞与细胞、细胞与细胞外基质（ECM）之间的相互作用、精原干细胞（SSCs）的增殖和分化。人类和动物实验表明，基于 ECM 的支架在体外精子发生方面具有潜在优势。此外，褪黑素具有很强的抗氧化和抗炎活性，可改善人类 SSCs 在体外培养条件下的操作。

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Melatonin Promotes Differentiation of Human Spermatogonial Stem Cells Cultured on Three-Dimensional Decellularized Human Testis Matrix.

The use of 3D (3-Dimensional) culture systems supported cell-to-cell and cell-to-extracellular matrix (ECM) interactions, proliferation, and differentiation of SSCs (Spermatogonial stem cells). The potential advantages of ECM-based scaffolds for in vitro spermatogenesis have been indicated in human and animal experiments. Furthermore, the strong antioxidant and anti-inflammatory activities of melatonin have improved in vitro manipulation of human SSCs in culture conditions.

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来源期刊

Urology Journal UROLOGY & NEPHROLOGY-

CiteScore

2.60

自引率

6.70%

发文量

审稿时长

6-12 weeks

期刊介绍： As the official journal of the Urology and Nephrology Research Center (UNRC) and the Iranian Urological Association (IUA), Urology Journal is a comprehensive digest of useful information on modern urology. Emphasis is on practical information that reflects the latest diagnostic and treatment techniques. Our objectives are to provide an exceptional source of current and clinically relevant research in the discipline of urology, to reflect the scientific work and progress of our colleagues, and to present the articles in a logical, timely, and concise format that meets the diverse needs of today’s urologist. Urology Journal publishes manuscripts on urology and kidney transplantation, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication. Accordingly, original articles, case reports, and letters to editor are encouraged.