基于 SERS 的生物检测进展及其在胰腺癌中的应用和展望

IF 9.7 4区医学 Q1 MATERIALS SCIENCE, BIOMATERIALS

VIEW Pub Date : 2023-12-17 DOI:10.1002/viw.20230070

Lei Xu, Yujiao Xie, Jie Lin, Aiguo Wu, Tianan Jiang

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引用次数: 0

摘要

表面增强拉曼光谱（SERS）已成为一种重要的生物检测技术。由于其灵敏度高、信号特异性好、抗光漂白等特点，SERS 已广泛应用于分子成像、肿瘤诊断和药物监测等生物医学研究领域。本综述主要介绍 SERS 在生物医学领域的应用进展。我们首先介绍了 SERS 的基本原理和基底研究进展。然后，我们总结了 SERS 在药物监测、细胞和外泌体检测、肿瘤成像以及结合微流控和横向流技术的检测平台等方面的最新研究进展。随后，介绍了 SERS 在胰腺癌早期诊断和药物疗效监测方面的应用研究。最后，提出了 SERS 在肿瘤诊断和治疗中的未来发展方向和可能面临的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Advancements in SERS-based biological detection and its application and perspectives in pancreatic cancer

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Advancements in SERS-based biological detection and its application and perspectives in pancreatic cancer

Surface-enhanced Raman spectroscopy (SERS) has become an essential bio-detection technique. Due to its high sensitivity, good signal specificity, and resistance to photobleaching, SERS has been widely used in biomedical research fields such as molecular imaging, tumor diagnosis, and drug monitoring. This review focuses on the progress of SERS in biomedical applications. We first introduce the basic principle of SERS and the progress of substrate research. Then, we summarize the latest research progress on SERS in drug monitoring, cell and exosome detection, tumor imaging, and detection platforms combining microfluidic and lateral flow technologies. Subsequently, the applied research of SERS in early diagnosis of pancreatic cancer and drug efficacy monitoring is described. Finally, the future development direction and possible challenges of SERS in tumor diagnosis and treatment are proposed.

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来源期刊

VIEW Multiple-

CiteScore

12.60

自引率

2.30%

发文量

审稿时长

10 weeks

期刊介绍： View publishes scientific articles studying novel crucial contributions in the areas of Biomaterials and General Chemistry. View features original academic papers which go through peer review by experts in the given subject area.View encourages submissions from the research community where the priority will be on the originality and the practical impact of the reported research.