Emily M. Esquea, Riley G. Young, Mauricio J. Reginato
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Fructose promotes liver cancer via microbial acetate-induced O-GlcNAcylation
High dietary fructose consumption is linked to multiple disease states, including cancer. Zhou and colleagues recently reported a novel mechanism where high dietary fructose levels increase acetate production by the gut microbiome increasing post-translational modification O-GlcNAcylation in liver cells, which contributes to disease progression in mouse models of hepatocellular carcinoma.
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