鸢尾素限制阿尔茨海默病中淀粉样蛋白-β的堆积

Trends in Endocrinology & Metabolism Pub Date : 2023-12-14 DOI:10.1016/j.tem.2023.11.006

Mychael V. Lourenco

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引用次数: 0

摘要

越来越多的证据表明，体育锻炼可以保护大脑免受神经退行性疾病的侵害。在Neuron杂志最近的一篇论文中，Kim等人报道了运动诱导的激素鸢尾素通过促进星形胶质细胞衍生的网溶素的分泌来抑制淀粉样蛋白-β的形成。这些发现可能有助于解释鸢尾素和运动对阿尔茨海默病的神经保护作用。

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Irisin limits amyloid-β buildup in Alzheimer’s disease

Mounting evidence suggests that physical exercise protects the brain against neurodegenerative disease. In a recent paper in Neuron, Kim et al. reported that the exercise-induced hormone irisin curbs amyloid-β buildup by promoting secretion of astrocyte-derived neprilysin. These findings may help explain the neuroprotection by irisin and exercise in Alzheimer’s disease.

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Trends in Endocrinology & Metabolism

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