冠状动脉纤维肌发育不良:一例不寻常的猝死病例及文献综述

IF 1.2 4区 医学 Q3 MEDICINE, LEGAL
Oumeima Brahim , Yosra Mahjoub , Marwa Boussaid , Hiba Limem , Abir Aissaoui
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引用次数: 0

摘要

冠状动脉纤维肌肉发育不良是一种罕见的冠状动脉缺陷,具有一系列病理改变和不可预测的临床描述,可导致猝死。我们提出一个解剖病例心脏猝死由于冠状动脉瘤破裂在一个59岁的妇女。尸检发现两个巨大的囊状动脉瘤位于右冠状动脉,其中一个破裂导致致命的心包积血。组织病理学检查显示冠状动脉纤维肌肉发育不良伴纤维黏液样分离引起囊状动脉瘤。纤维肌肉发育不良伴动脉瘤样特征的冠状动脉受累在文献中很少报道,而且很可能是未被诊断的发现。由于发表的研究较少,其病因尚不完全清楚,发病机制、危险因素、表现、病程、死亡率等数据尚不清楚,这是一个需要填补的空白,以避免疾病的漏诊。我们的病例报告旨在探讨猝死的机制归因于冠状动脉纤维肌肉发育不良。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fibromuscular dysplasia of the coronary arteries: An unusual case of sudden death and review of the literature

Fibromuscular dysplasia of the coronary is an uncommon coronary defect with a range of pathological alterations and unpredictable clinical description that can cause sudden death.

We present an autopsy case of sudden cardiac death due to a rupture of a coronary artery aneurysm in a 59-year-old woman. Postmortem autopsy revealed two huge saccular aneurysms located at the right coronary artery, one of which was ruptured leading to a fatal hemopericardium. Histopathological examination revealed coronary artery fibromuscular dysplasia with fibromyxoid dissociation of the media causing saccular aneurysms. The involvement of coronary arteries in fibromuscular dysplasia with aneurysmal features has been rarely reported in the literature and is most likely an underdiagnosed finding. Due to the little number of published studies, the etiology is not fully understood and data on pathogenesis, risk factors, manifestation, disease course, and mortality are still unclear, which is a gap that needs to be filled in order to avoid under-diagnosis of the disease.

Our case report aimed to discuss the mechanisms of sudden death attributed to coronary fibromuscular dysplasia.

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来源期刊
CiteScore
2.70
自引率
6.70%
发文量
106
审稿时长
57 days
期刊介绍: The Journal of Forensic and Legal Medicine publishes topical articles on aspects of forensic and legal medicine. Specifically the Journal supports research that explores the medical principles of care and forensic assessment of individuals, whether adult or child, in contact with the judicial system. It is a fully peer-review hybrid journal with a broad international perspective. The Journal accepts submissions of original research, review articles, and pertinent case studies, editorials, and commentaries in relevant areas of Forensic and Legal Medicine, Context of Practice, and Education and Training. The Journal adheres to strict publication ethical guidelines, and actively supports a culture of inclusive and representative publication.
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