与异种移植产品生物安全监测有关的猪巨细胞病毒/绒毛膜病毒检测方法比较

IF 3.3 4区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Xenotransplantation Pub Date : 2023-12-13 DOI:10.1111/xen.12835

Joachim Denner, Hina Jhelum, Sabrina Hansen, Benedikt B. Kaufer

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引用次数: 0

摘要

猪巨细胞病毒是猪玫瑰病毒(PCMV/PRV)的一种，广泛分布于猪群中。已有研究表明，PCMV/PRV通过猪异种移植传播给非人灵长类动物，并显著缩短了受体的存活时间。PCMV/PRV也在首次猪心脏移植到人类患者体内时传播。PCMV/PRV在宿主体内建立终身持续感染(潜伏期)，在这一阶段很难被发现，因此对未来的临床异种移植构成威胁。因此，在筛选供体猪时，应采用敏感而具体的方法和目标导向的策略，即如何、何时、何地进行检测。

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Comparison of methods for the detection of porcine cytomegalovirus/roseolovirus in relation to biosafety monitoring of xenotransplantation products

The porcine cytomegalovirus, a porcine roseolovirus (PCMV/PRV), is widely distributed in pig populations. It has been shown that PCMV/PRV was transmitted by pig xenotransplants to non-human primates, and significantly reduced the survival time of the recipient. PCMV/PRV was also transmitted during the first transplantation of a pig heart into a human patient. PCMV/PRV establishes a lifelong persistent infection (latency) in the host, is difficult to detect in this stage, and consequential poses a threat to future clinical xenotransplantations. Therefore, sensitive and specific methods and goal-oriented strategies how, when, and where to test should be used for screening donor pigs.

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来源期刊

Xenotransplantation 医学-医学：研究与实验

CiteScore

6.80

自引率

15.40%

发文量

审稿时长

>12 weeks

期刊介绍： Xenotransplantation provides its readership with rapid communication of new findings in the field of organ and tissue transplantation across species barriers.The journal is not only of interest to those whose primary area is xenotransplantation, but also to veterinarians, microbiologists and geneticists. It also investigates and reports on the controversial theological, ethical, legal and psychological implications of xenotransplantation.