Rab11 家族互作蛋白 4 在子痫前期发病中的生物学功能及其内在机制

IF 2.9 4区 医学 Q1 Medicine
Shanshan Yang, Guixia Sun, Yanxia Zhang
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引用次数: 0

摘要

阐明Rab11-FIP4在子痫前期发生发展中的生物学功能及其临床意义和机制。采用qRT-PCR检测PE孕妇与健康孕妇胎盘组织中Rab11-FIP4、IL-6、TNF-α的相对水平。采用Pearson相关检验评估Rab11-FIP4与IL-6或TNF-α的相关性。构建Rab11-FIP4过表达慢病毒后,检测其对HTR-8/SVneo细胞生物学特性及炎症因子表达水平的影响。Rab11-FIP4在PE孕妇胎盘组织中高表达。Rab11-FIP4的过表达增强了滋养细胞的迁移和侵袭能力,上调了炎症蛋白。Rab11-FIP4通过上调炎症蛋白,刺激滋养细胞的迁移和侵袭能力,从而加剧PE的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biological Function of Rab11-Family Interacting Protein 4 in the Development of Preeclampsia and Their Underlying Mechanism
To elucidate the biological function of Rab11-FIP4 in the development of preeclampsia, as well as its clinical significance and underlying mechanism. Relative levels of Rab11-FIP4, IL-6 and TNF-α in placental tissues of PE pregnant women and healthy pregnant women were detected by qRT-PCR. The correlation between Rab11-FIP4 and IL-6 or TNF-α was assessed by Pearson correlation test. After constructing overexpression lentivirus targeting Rab11-FIP4, its influences on biological characteristics of HTR-8/SVneo cells and expression levels of inflammatory cytokines were examined. Rab11-FIP4 was highly expressed in placental tissues of PE pregnant women. Overexpression of Rab11-FIP4 enhanced migratory and invasive capacities of trophoblasts, and upregulated inflammatory proteins. Rab11-FIP4 aggravates the development of PE by upregulating inflammatory proteins, and stimulating migratory and invasive capacities of trophoblasts.
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来源期刊
CiteScore
4.30
自引率
17.20%
发文量
145
审稿时长
2.3 months
期刊介绍: Information not localized
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