连洁丽妍复合混合物的测定与方法优化

IF 0.5 4区 医学
Min Jiang, Yin Lin, Jinghua Li, Haoran Yang, Yingquan Fang
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引用次数: 0

摘要

连节理炎复方合剂是治疗咽炎、喉癌等咽喉疾病的复方制剂,是由真丝、桔梗、白桦、四叶参组成的四种药用物质。该制剂已在临床上使用了很长时间,并已被证明在减轻疼痛和其他症状方面具有疗效。但目前尚未对该制剂进行质量控制研究。对主要质量控制标准中的药理学成分,桔梗中的氧化苦参碱、苦参碱、n -甲基胱氨酸、桔梗中的桔梗苷- d、蛇柑中的鸢尾黄素进行分析,进一步规范该制剂在临床上的合理使用,防止不良反应和副作用的发生。在本研究中,首次采用Box-Behnken设计和响应面法同时测定了混合物中的五种有效成分。通过对HPLC测定条件的优化,所建立的模型具有良好的分辨率和灵敏度,重现性和速度好,预测准确等特点。所建立的方法准确可靠,为连节理炎复方合剂的配制及质量控制提供了有益的支持和参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Determination and Method Optimization of Lianjie Liyan Compound Mixture
Euchresta japonica, Platycodon grandiflorum, Belamcanda chinensis, and Adenophora tetraphylla are the four medicinal substances that make up the Lianjie Liyan compound mixture, a type of compound preparation for treating throat diseases such as pharyngitis and laryngeal carcinoma. The preparation has been used clinically for a long time and has been proven that it has curative properties in terms of alleviating pain and other symptoms. However, no quality control research on this preparation has been done yet. The pharmacological components in the main quality control standards, including Oxymatrine, matrine, N-methylcytisine, platycoside-D in Platycodon grandiflorum, and irisaxanthin in Shegan, were analyzed to further standardize the clinically rational use of this preparation and prevent the occurrence of adverse reactions and side effects. In this study, the five active components in the mixture were determined concurrently for the first time with the help of Box-Behnken design and response surface approach. The properties of established model showed excellent resolution and sensitivity, good reproducibility and speed, and accurate prediction thanks to the optimization of HPLC measurement conditions. The established approach was precise and trustworthy, and it offered helpful support and references for the construction of the Lianjie Liyan compound mixture as well as for the quality control.
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来源期刊
Journal of Biobased Materials and Bioenergy
Journal of Biobased Materials and Bioenergy 工程技术-材料科学:生物材料
自引率
0.00%
发文量
60
审稿时长
6 months
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