运动医学原理增强了使用姜黄素负载纳米复合水凝胶治疗大鼠脊髓损伤模型的愈合反应

IF 2.9 4区医学 Q1 Medicine

Journal of biomedical nanotechnology Pub Date : 2023-12-01 DOI:10.1166/jbn.2023.3564

Bo Zhao, Hao Huang

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引用次数: 0

摘要

本研究在大鼠脊髓损伤模型中探讨了规律运动对脊髓损伤愈合反应的潜在愈合功能。这些动物被姜黄素负载的壳聚糖纳米颗粒分散在含有子宫内膜干细胞的海藻酸钙水凝胶中。研究表明，与其他组相比，同时接受定期运动和水凝胶治疗的动物表现出明显更好的组织病理学指标和功能恢复。组织病理学研究显示，该组水肿、空泡化和纤维化明显降低。基因表达研究表明，杂交处理上调了VEGF、b-FGF和TGF-β基因的表达水平。

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Sport Medicine Principles Augment Healing Response in Spinal Cord Injury in a Rat Model Treated with a Curcumin-Loaded Nanocomposite Hydrogel

In this research, the potential healing function of regular exercise on spinal cord injury healing response was investigated in a rat model. The animals were treated with curcumin-loaded chitosan nanoparticles dispersed in a calcium alginate hydrogel containing endometrial stem cells. Study showed the animals that received both regular exercise and hydrogel showed significantly better histopathological signs and functional recovery than the other groups. Histopathological studies showed that edema, vacuolation, and fibrosis were significantly lower in this group. Gene expression studies showed that the hybrid treatment upregulated the expression levels of VEGF, b-FGF, and TGF-β genes.

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来源期刊

Journal of biomedical nanotechnology 医学-纳米科技

CiteScore

4.30

自引率

17.20%

发文量

145

审稿时长

2.3 months

期刊介绍： Information not localized