奥贡州阿贝奥库塔市部分三级医院艾滋病患者的人口分布模式和抗逆转录病毒疗法状况

Adijat O.A, Oluwasegun B.K, Thaddaeus O.A, Henry T.O, Olufunke B.S
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摘要

人类免疫缺陷病毒(艾滋病毒)在尼日利亚的发病率相对较高,并且由于抗逆转录病毒治疗(ART)的覆盖率较低而受到影响。本研究旨在探讨抗逆转录病毒治疗对血清阳性个体CD4细胞计数的影响。收集阿贝奥库塔市3家转诊医院HIV患者的血液样本,采用流式细胞术检测CD4细胞计数。患者的社会人口统计数据也被收集并使用STATA/IC进行分析。从三家医院共采集了615份血清阳性血液样本。男女比例为2:1,其中20 ~ 40岁年龄组感染人数最多(63.3%)。已婚人群的艾滋病毒感染率(52%)高于单身人群(26.8%),受过初等或中等教育的人群感染率最高(42.4%),高于受过高等教育的人群(36.7%)和没有受过正规教育的人群(9.1%)。CD4计数显示,51.2%的感染者CD4计数在100-200 cells/µL之间,5.2%的感染者CD4计数在200 cells/µL以上。在接受抗逆转录病毒治疗的感染者中,只有47.3%的人CD4细胞计数(132.1±4.23)高于未接受抗逆转录病毒治疗的感染者(98.67±3.56)。作为有效管理奥贡州艾滋病毒和实现美国艾滋病规划署2030年既定目标的一种方式,需要进行更多的艾滋病毒筛查,以便及早开始抗逆转录病毒治疗,以抑制病毒载量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Demographic Distribution Pattern and Antiretroviral Therapy Status Among HIV Patients in Selected Tertiary Hospitals in Abeokuta, Ogun State
The occurrence of human immunodeficiency virus (HIV) in Nigeria is relatively high and compromised with low antiretroviral therapy (ART) coverage. The study aimed at investigating the effect of ART on the CD4 cell count among seropositive individuals. Blood samples of HIV patients visiting three referral hospitals in Abeokuta were collected and CD4 cell count determined via flow cytometry method. Socio-demographic data of patients were also collected and analyzed using STATA/IC. A total of 615 seropositive blood samples were collected from three hospitals. The female to male ratio was found to be 2:1 of which age bracket 20-40 years had the highest infective number (63.3%) among other age categories. There was higher HIV occurrence among the married (52%) than the single (26.8%), while those with primary or secondary education had the highest (42.4%) compared to tertiary education (36.7%) and no formal education (9.1%). The CD4 count of infected cases showed that 51.2% had CD4 count between 100-200 cells/µL with 5.2% above 200 cells/µL. Also only 47.3% of the total infected cases placed on ART had a mean CD4 cell count (132.1±4.23) higher than those not on ART (CD4 count = 98.67±3.56). As a way of effectively managing HIV in Ogun State and meeting the 2030 set goal of USAIDS there is need for more HIV screening for early commencement of ART towards suppressing viral load.
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