氧化还原敏感基因的多态性在肥胖和代谢性疾病的氧化应激机制中的作用

Q3 Agricultural and Biological Sciences
M. Shkurat, E. V. Mashkina, Natalya P. Milyutina, T. P. Shkurat
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引用次数: 0

摘要

本文综述了氧化还原敏感基因多态性变异在肥胖和相关代谢疾病中调节氧化应激发展的作用。考虑了氧化应激的概念,活性氧代谢产物(AOM),包括氧、氮和氯的活性形式,并给出了抗氧化系统及其酶联系的概念。研究表明,产生aom的酶CYBA、CYBB、MT-ND1/2/4L、MT-CO1/3、XOR、CYP、NOS2/3、MPO -基因多态性在肥胖症氧化应激诱导中的重要作用。强调AOM在肥胖中的二重性:一方面,它们是正常脂肪形成和信号传递所必需的,另一方面,它们在氧化应激的发生中起触发作用。研究表明,肥胖和代谢性疾病中抗氧化系统的失衡可能与关键抗氧化酶和蛋白SOD1/2/3、CAT、GPX1-8、GSR、GSTP1、GSTM1、GSTT1、PRDX3、TXNIP、HMOX1、NQO1、NFE2L2、KEAP1基因的变异有关。Nrf2转录因子基因是生理条件和肥胖中氧化还原稳态的主要调节因子,其多态性的关键作用已得到证实。已经证明,由于促氧化-抗氧化系统的遗传变异导致氧化还原稳态的破坏有助于病理性肥胖表型的发展。了解肥胖和代谢性疾病中氧化应激的遗传机制,对于扩大对这些疾病发病机制的认识,并制定有效的纠正方法是必要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of polymorphism of redox-sensitive genes in the mechanisms of oxidative stress in obesity and metabolic diseases
The review summarizes ideas about the role of polymorphic variants of redox-sensitive genes that regulate the development of oxidative stress in obesity and associated metabolic diseases. The concept of oxidative stress, activated oxygen metabolites (AOM), which include reactive forms of oxygen, nitrogen, and chlorine, is considered, and an idea of the antioxidant system and its enzymatic link is given. The important role of gene polymorphism of AOM-producing enzymes — CYBA, CYBB, MT-ND1/2/4L, MT-CO1/3, XOR, CYP, NOS2/3, MPO — in the induction of oxidative stress in obesity has been shown. The dualism of AOM in obesity is emphasized: on the one hand, they are necessary for normal adipogenesis and signaling, and, on the other hand, they play a trigger role in the development of oxidative stress. It has been demonstrated that an imbalance in antioxidant system in obesity and metabolic disorders may be associated with variability in the genes of key antioxidant enzymes and proteins — SOD1/2/3, CAT, GPX1-8, GSR, GSTP1, GSTM1, GSTT1, PRDX3, TXNIP, HMOX1, NQO1, NFE2L2, KEAP1. The critical role of polymorphism in the Nrf2 transcription factor gene, the main regulator of redox homeostasis under physiological conditions and in obesity, has been demonstrated. It has been demonstrated that disruption of redox homeostasis due to genetic variability of the prooxidant-antioxidant system contributes to the development of the pathological obesity phenotype. Understanding the genetic mechanisms underlying oxidative stress in obesity and metabolic diseases is necessary to expand knowledge about the mechanisms of pathogenesis of these diseases and to develop effective methods for their correction.
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来源期刊
Ecological genetics
Ecological genetics Environmental Science-Ecology
CiteScore
0.90
自引率
0.00%
发文量
22
期刊介绍: The journal Ecological genetics is an international journal which accepts for consideration original manuscripts that reflect the results of field and experimental studies, and fundamental research of broad conceptual and/or comparative context corresponding to the profile of the Journal. Once a year, the editorial Board reviews and, if necessary, corrects the rules for authors and the journal rubrics.
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