Origin of stage I-II retinopathy

Aim – to study the causes of retinopathy (RP) formation and progression at the initial stages. Material and methods. The data of a 6-year prospective follow-up of a natural group of initially healthy male workers aged 18-66 years (n = 7,959) were used to determine the predictors of stage I-II RP. For this purpose, a 2×2 confusion matrix and a multivariate regression model were used, and the relative risk factors were assessed. Results. Stage I-II retinopathy was caused by such factors as age from 26 to 66 years, arterial hypertension, smoking, dyslipidemia, hyperglycemia, family history of early cardiovascular diseases, degree I-III obesity, left ventricular myocardial hypertrophy, microalbuminuria, type 2 diabetes mellitus, creatininemia, atherosclerotic plaque / thickening of the intima-media complex, aortic atherosclerosis. All predictors except for smoking, degree I-III obesity and aortic atherosclerosis had a statistically significant result in the applied mathematical models. Conclusion. Statistical heterogeneity of the stage I-II RP predictors is likely to be related to the qualitative specific characteristics of RP predictors and their unique damage effect in the development of stage I-II RP.