Izabela Jałocha , Michał Ławiński , Katarzyna Zadka , Maima Matin , Aneta Jachnis , Anna Ukleja , Anna Charuta , Jarosław O. Horbańczuk , Maciej Słodkowski , Atanas G. Atanasov
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This study aimed to assess the impact of home enteral nutrition (HEN) planned with the use of indirect calorimetry on the nutritional status and body composition of cancer patients.</p></div><div><h3>Methods</h3><p>This prospective, observational study included 28 patients with cancer recruited at the Nutrition Clinic of Department of General, Gastroenterologic and Oncologic Surgery, of the Medical University of Warsaw from December 2021 to December 2022. All patients were supported with HEN setup based on individual caloric needs for 3 months. We evaluated nutritional status, body composition, and biochemical markers of malnutrition.</p></div><div><h3>Results</h3><p>For 67.9 % of patients, using the equations rather than indirect calorimetry would underestimate energy needs. Individualized HEN resulted in weight loss stops in 46.4 % of patients. The average change in body mass in the study group was positive and was equal to 0.46 ± 6.73 kg. No significant differences were found when comparing the mid-arm circumference (MAC) and triceps skinfold thickness (SFT) before and after inclusion in HEN, although, as in the case of body mass SFT showed an upward trend. Moreover, the percentage of patients with insufficient total protein (TP) and serum albumin concentrations decreased. This difference was statistically significant for albumin. The Nutritional Risk Index (NRI) was also significantly higher. The analysis of body composition also showed a decrease in the percentage of patients with reduced fat-free mass (FFM), body cell mass (BCM), and phase angle (PhA) value.</p></div><div><h3>Conclusions</h3><p>The results of our research highlight the significance of well-planned nutritional care for cancer patients. Utilizing HEN and individualized approaches can effectively preserve body mass, composition, and nutritional status while minimizing safety risks, ultimately improving quality of life. Indirect calorimetry if available can be helpful to optimize nutrition care for patients with cancer in HEN.</p></div>","PeriodicalId":52676,"journal":{"name":"Current Research in Biotechnology","volume":null,"pages":null},"PeriodicalIF":3.6000,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590262823000424/pdfft?md5=01d1b8d8e4d9f05da766b88946847e06&pid=1-s2.0-S2590262823000424-main.pdf","citationCount":"0","resultStr":"{\"title\":\"The impact of home enteral nutrition planned with the use of indirect calorimetry on the nutritional status and body composition of cancer patients\",\"authors\":\"Izabela Jałocha , Michał Ławiński , Katarzyna Zadka , Maima Matin , Aneta Jachnis , Anna Ukleja , Anna Charuta , Jarosław O. Horbańczuk , Maciej Słodkowski , Atanas G. 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This study aimed to assess the impact of home enteral nutrition (HEN) planned with the use of indirect calorimetry on the nutritional status and body composition of cancer patients.</p></div><div><h3>Methods</h3><p>This prospective, observational study included 28 patients with cancer recruited at the Nutrition Clinic of Department of General, Gastroenterologic and Oncologic Surgery, of the Medical University of Warsaw from December 2021 to December 2022. All patients were supported with HEN setup based on individual caloric needs for 3 months. We evaluated nutritional status, body composition, and biochemical markers of malnutrition.</p></div><div><h3>Results</h3><p>For 67.9 % of patients, using the equations rather than indirect calorimetry would underestimate energy needs. Individualized HEN resulted in weight loss stops in 46.4 % of patients. The average change in body mass in the study group was positive and was equal to 0.46 ± 6.73 kg. 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引用次数: 0
摘要
背景研究表明，营养不良在癌症患者中很常见，约占 20% 到 70% 以上。众所周知，营养不良如果得不到妥善处理，会使病情恶化，延长住院时间，影响生活质量和治疗毒性。营养不良有很多负面影响，因此，个性化和优化营养支持对患者的健康至关重要。本研究旨在评估使用间接热量计计划的家庭肠内营养（HEN）对癌症患者营养状况和身体组成的影响。方法这项前瞻性观察研究纳入了华沙医科大学普通外科、胃肠外科和肿瘤外科营养诊所从 2021 年 12 月至 2022 年 12 月招募的 28 名癌症患者。所有患者都根据个人热量需求接受了为期 3 个月的 HEN 治疗。我们对营养状况、身体成分和营养不良的生化指标进行了评估。结果67.9%的患者使用方程而非间接热量计会低估能量需求。个体化 HEN 使 46.4% 的患者体重减轻。研究组体重的平均变化为正值，等于 0.46 ± 6.73 千克。中臂围（MAC）和肱三头肌皮褶厚度（SFT）在纳入 HEN 前后的比较中未发现明显差异，但与体重一样，肱三头肌皮褶厚度呈上升趋势。此外，总蛋白（TP）和血清白蛋白浓度不足的患者比例也有所下降。就白蛋白而言，这一差异具有统计学意义。营养风险指数（NRI）也明显升高。对身体成分的分析还显示，无脂肪质量（FFM）、体细胞质量（BCM）和相位角（PhA）值降低的患者比例也有所下降。利用 HEN 和个体化方法可以有效保持身体质量、组成和营养状况，同时最大限度地降低安全风险，最终提高生活质量。如果可以使用间接热量计，则有助于优化 HEN 中癌症患者的营养护理。
The impact of home enteral nutrition planned with the use of indirect calorimetry on the nutritional status and body composition of cancer patients
Background
Studies show that malnutrition is common among cancer patients, ranging from about 20% to more than 70%. It is known that malnutrition that is not managed properly worsens the course of the disease, prolongs the hospital stay, and impacts the quality of life and treatment toxicities. Malnutrition has many negative effects, therefore individualization and optimization of nutritional support is crucial for the patient's health. This study aimed to assess the impact of home enteral nutrition (HEN) planned with the use of indirect calorimetry on the nutritional status and body composition of cancer patients.
Methods
This prospective, observational study included 28 patients with cancer recruited at the Nutrition Clinic of Department of General, Gastroenterologic and Oncologic Surgery, of the Medical University of Warsaw from December 2021 to December 2022. All patients were supported with HEN setup based on individual caloric needs for 3 months. We evaluated nutritional status, body composition, and biochemical markers of malnutrition.
Results
For 67.9 % of patients, using the equations rather than indirect calorimetry would underestimate energy needs. Individualized HEN resulted in weight loss stops in 46.4 % of patients. The average change in body mass in the study group was positive and was equal to 0.46 ± 6.73 kg. No significant differences were found when comparing the mid-arm circumference (MAC) and triceps skinfold thickness (SFT) before and after inclusion in HEN, although, as in the case of body mass SFT showed an upward trend. Moreover, the percentage of patients with insufficient total protein (TP) and serum albumin concentrations decreased. This difference was statistically significant for albumin. The Nutritional Risk Index (NRI) was also significantly higher. The analysis of body composition also showed a decrease in the percentage of patients with reduced fat-free mass (FFM), body cell mass (BCM), and phase angle (PhA) value.
Conclusions
The results of our research highlight the significance of well-planned nutritional care for cancer patients. Utilizing HEN and individualized approaches can effectively preserve body mass, composition, and nutritional status while minimizing safety risks, ultimately improving quality of life. Indirect calorimetry if available can be helpful to optimize nutrition care for patients with cancer in HEN.
期刊介绍：
Current Research in Biotechnology (CRBIOT) is a new primary research, gold open access journal from Elsevier. CRBIOT publishes original papers, reviews, and short communications (including viewpoints and perspectives) resulting from research in biotechnology and biotech-associated disciplines.
Current Research in Biotechnology is a peer-reviewed gold open access (OA) journal and upon acceptance all articles are permanently and freely available. It is a companion to the highly regarded review journal Current Opinion in Biotechnology (2018 CiteScore 8.450) and is part of the Current Opinion and Research (CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists' workflow.
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