多聚胞抑制复合体 2 辅助因子：细胞命运决定的调节器？

IF 3.7 2区生物学 Q2 CELL BIOLOGY

Current Opinion in Genetics & Development Pub Date : 2023-12-12 DOI:10.1016/j.gde.2023.102137

Hina Bharti , Sungwook Han , Han-Wen Chang , Danny Reinberg

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引用次数: 0

摘要

发育过程中的表观遗传重编程是细胞特性的关键，而多聚核抑制复合体的活动对这一过程至关重要。我们重点研究多聚核抑制复合体2（PRC2），它催化H3K27me1/2/3，通过确保适当的基因抑制来保障细胞的完整性。值得注意的是，各种附属因子与 PRC2 相关联，对细胞命运的决定有很大影响，它们的失调会导致各种疾病。然而，这些因子在发育和癌变过程中的确切作用还不完全清楚。在此，我们介绍了解决这些问题的最新进展，并分析了 PRC2 辅助因子在不同组织和发育阶段的表达水平，以突出它们的丰度和作用。最后，我们评估了它们对癌症特异性表型的贡献，从而为新型抗癌疗法提供启示。

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Polycomb repressive complex 2 accessory factors: rheostats for cell fate decision?

Epigenetic reprogramming during development is key to cell identity and the activities of the Polycomb repressive complexes are vital for this process. We focus on polycomb repressive complex 2 (PRC2), which catalyzes H3K27me1/2/3 and safeguards cellular integrity by ensuring proper gene repression. Notably, various accessory factors associate with PRC2, strongly influencing cell fate decisions, and their deregulation contributes to various illnesses. Yet, the exact role of these factors during development and carcinogenesis is not fully understood. Here, we present recent progress toward addressing these points and an analysis of the expression levels of PRC2 accessory factors in various tissues and developmental stages to highlight their abundance and roles. Last, we evaluate their contribution to cancer-specific phenotypes, providing insight into novel anticancer therapies.

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来源期刊

Current Opinion in Genetics & Development 生物-细胞生物学

CiteScore

7.90

自引率

0.00%

发文量

102

审稿时长

1 months

期刊介绍： Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)