人类大脑皮层呼吸感觉门控的神经振荡标记

IF 4.1 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
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引用次数: 0

摘要

背景人类呼吸感觉门控是一个与抑制大脑皮层处理重复呼吸机械刺激有关的神经过程。虽然这种门控通常是在时域中进行研究,但神经振荡动力学可以为呼吸感觉门控提供补充见解,而这种神经振荡动力学仍然是未知的。本研究的目的是通过时域和频域分析来研究呼吸感觉的中枢神经门控。在一次吸气中出现两次瞬时吸气闭塞,同时记录脑电图(EEG)中的反应。测量了第一个刺激(S1)和第二个刺激(S2)的 N1 振幅和振荡活动。实验结束后,对闭塞引起的窒息感和不愉快感进行了测量。结果正如预期的那样,S1 的 N1 峰值振幅明显大于 S2。N1 峰值振幅的平均呼吸感觉门控 S2/S1 比率为 0.71。对于诱发振荡和诱导振荡,时频分析表明,相对于 S2,S1 的θ激活更高。我们的结果表明,θ 振荡(诱发和诱导)反映了呼吸感觉的 "门控"。θ振荡,尤其是θ诱导功率,可能表明了呼吸机械感觉的情绪处理过程。本研究的发现为今后研究呼吸感觉门控的内在机制奠定了基础,尤其是在病人群体中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neural oscillatory markers of respiratory sensory gating in human cortices

Background

Human respiratory sensory gating is a neural process associated with inhibiting the cortical processing of repetitive respiratory mechanical stimuli. While this gating is typically examined in the time domain, the neural oscillatory dynamics, which could offer supplementary insights into respiratory sensory gating, remain unknown. The purpose of the present study was to investigate central neural gating of respiratory sensation using both time- and frequency-domain analyses.

Methods

A total of 37 healthy adults participated in this study. Two transient inspiratory occlusions were presented within one inspiration, while responses in the electroencephalogram (EEG) were recorded. N1 amplitudes and oscillatory activities to the first stimulus (S1) and the second stimulus (S2) were measured. The perceived level of breathlessness and level of unpleasantness elicited by the occlusions were measured after the experiment.

Results

As expected, the N1 peak amplitude to the S1 was significantly larger than to the S2. The averaged respiratory sensory gating S2/S1 ratio for the N1 peak amplitude was 0.71. For both the evoked- and induced-oscillations, time-frequency analysis showed higher theta activations in response to S1 relative to S2. A positive correlation was observed between the perceived unpleasantness and induced theta power.

Conclusions

Our results suggest that theta oscillations, evoked as well as induced, reflect the “gating” of respiratory sensation. Theta oscillation, particularly theta-induced power, may be indicative of the emotional processing of respiratory mechanosensation. The findings of this study serve as a foundation for future investigations into the underlying mechanisms of respiratory sensory gating, particularly in patient populations.

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来源期刊
Biomedical Journal
Biomedical Journal Medicine-General Medicine
CiteScore
11.60
自引率
1.80%
发文量
128
审稿时长
42 days
期刊介绍: Biomedical Journal publishes 6 peer-reviewed issues per year in all fields of clinical and biomedical sciences for an internationally diverse authorship. Unlike most open access journals, which are free to readers but not authors, Biomedical Journal does not charge for subscription, submission, processing or publication of manuscripts, nor for color reproduction of photographs. Clinical studies, accounts of clinical trials, biomarker studies, and characterization of human pathogens are within the scope of the journal, as well as basic studies in model species such as Escherichia coli, Caenorhabditis elegans, Drosophila melanogaster, and Mus musculus revealing the function of molecules, cells, and tissues relevant for human health. However, articles on other species can be published if they contribute to our understanding of basic mechanisms of biology. A highly-cited international editorial board assures timely publication of manuscripts. Reviews on recent progress in biomedical sciences are commissioned by the editors.
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