Kelvin K.C. Ng , Hon-Ting Lok , Kit-Fai Lee , Tan-To Cheung , Nam-Hung Chia , Wai-Kuen Ng , Cho-Kwan Law , Chung-Yeung Cheung , Kai-Chi Cheng , Sunny Y.S. Cheung , Paul B.S. Lai
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Univariate and multivariate analyses were performed to identify prognostic factors affecting survival.</p></div><div><h3>Results</h3><p><span>There were 133 patients in the NCNNLM group and 266 patients in the CLM group. The mortality (1.5 % vs 1.5 %) and morbidity (19.5 % vs 20.3 %) rates were comparable between the two groups. There was no statistically significant difference in 5-year overall (48.9 % vs 39.8 %) and recurrence-free (25.1 % vs 23.4 %) survival rates between NCNNLM and CLM groups. A high pre-operative serum bilirubin level, severe </span>postoperative complications<span> and multiple tumors were independent prognostic factors for poor survival.</span></p></div><div><h3>Conclusion</h3><p>Hepatectomy for selected patients with NCNNLM can achieve similar long-term oncological outcomes as those with CLM. High serum bilirubin, severe postoperative complication and multiple tumors are poor prognostic factors for survival.</p></div>","PeriodicalId":49463,"journal":{"name":"Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparison of post-hepatectomy long-term survival outcome between non-colorectal non-neuroendocrine and colorectal liver metastases: A population-based propensity-score matching analysis\",\"authors\":\"Kelvin K.C. Ng , Hon-Ting Lok , Kit-Fai Lee , Tan-To Cheung , Nam-Hung Chia , Wai-Kuen Ng , Cho-Kwan Law , Chung-Yeung Cheung , Kai-Chi Cheng , Sunny Y.S. Cheung , Paul B.S. Lai\",\"doi\":\"10.1016/j.surge.2023.11.007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p><span>Hepatectomy<span> is an established treatment for </span></span>colorectal liver metastasis<span> (CLM) or neuroendocrine liver metastasis. However, its role in non-colorectal non-neuroendocrine liver metastasis (NCNNLM) is controversial. This study aims to compare long-term survival outcomes after hepatectomy between NCNNLM and CLM in a population-based cohort.</span></p></div><div><h3>Methods</h3><p>From 2009 to 2018, curative hepatectomy were performed in 964 patients with NCNNLM (n = 133) or CLM (n = 831). Propensity score (PS) matching was performed. Short-term and long-term outcomes were compared between PS-matched groups. Univariate and multivariate analyses were performed to identify prognostic factors affecting survival.</p></div><div><h3>Results</h3><p><span>There were 133 patients in the NCNNLM group and 266 patients in the CLM group. The mortality (1.5 % vs 1.5 %) and morbidity (19.5 % vs 20.3 %) rates were comparable between the two groups. There was no statistically significant difference in 5-year overall (48.9 % vs 39.8 %) and recurrence-free (25.1 % vs 23.4 %) survival rates between NCNNLM and CLM groups. A high pre-operative serum bilirubin level, severe </span>postoperative complications<span> and multiple tumors were independent prognostic factors for poor survival.</span></p></div><div><h3>Conclusion</h3><p>Hepatectomy for selected patients with NCNNLM can achieve similar long-term oncological outcomes as those with CLM. High serum bilirubin, severe postoperative complication and multiple tumors are poor prognostic factors for survival.</p></div>\",\"PeriodicalId\":49463,\"journal\":{\"name\":\"Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2023-12-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1479666X23001415\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"SURGERY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1479666X23001415","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0
摘要
背景肝切除术是治疗结直肠肝转移（CLM）或神经内分泌肝转移的一种成熟疗法。然而，它在非结直肠非神经内分泌肝转移（NCNNLM）中的作用却存在争议。本研究旨在比较基于人群的队列中NCNNLM和CLM肝转移瘤肝切除术后的长期生存结果。方法从2009年到2018年，对964例NCNNLM（n = 133）或CLM（n = 831）患者进行了治愈性肝切除术。进行了倾向评分（PS）匹配。比较了 PS 匹配组的短期和长期预后。结果NCNLM组有133名患者，CLM组有266名患者。两组的死亡率（1.5% 对 1.5%）和发病率（19.5% 对 20.3%）相当。NCNLM组和CLM组的5年总生存率（48.9% vs 39.8%）和无复发生存率（25.1% vs 23.4%）在统计学上没有明显差异。术前血清胆红素水平高、术后并发症严重和多发肿瘤是预后不良的独立因素。高血清胆红素、严重术后并发症和多发肿瘤是预后不良的生存因素。
Comparison of post-hepatectomy long-term survival outcome between non-colorectal non-neuroendocrine and colorectal liver metastases: A population-based propensity-score matching analysis
Background
Hepatectomy is an established treatment for colorectal liver metastasis (CLM) or neuroendocrine liver metastasis. However, its role in non-colorectal non-neuroendocrine liver metastasis (NCNNLM) is controversial. This study aims to compare long-term survival outcomes after hepatectomy between NCNNLM and CLM in a population-based cohort.
Methods
From 2009 to 2018, curative hepatectomy were performed in 964 patients with NCNNLM (n = 133) or CLM (n = 831). Propensity score (PS) matching was performed. Short-term and long-term outcomes were compared between PS-matched groups. Univariate and multivariate analyses were performed to identify prognostic factors affecting survival.
Results
There were 133 patients in the NCNNLM group and 266 patients in the CLM group. The mortality (1.5 % vs 1.5 %) and morbidity (19.5 % vs 20.3 %) rates were comparable between the two groups. There was no statistically significant difference in 5-year overall (48.9 % vs 39.8 %) and recurrence-free (25.1 % vs 23.4 %) survival rates between NCNNLM and CLM groups. A high pre-operative serum bilirubin level, severe postoperative complications and multiple tumors were independent prognostic factors for poor survival.
Conclusion
Hepatectomy for selected patients with NCNNLM can achieve similar long-term oncological outcomes as those with CLM. High serum bilirubin, severe postoperative complication and multiple tumors are poor prognostic factors for survival.
期刊介绍：
Since its establishment in 2003, The Surgeon has established itself as one of the leading multidisciplinary surgical titles, both in print and online. The Surgeon is published for the worldwide surgical and dental communities. The goal of the Journal is to achieve wider national and international recognition, through a commitment to excellence in original research. In addition, both Colleges see the Journal as an important educational service, and consequently there is a particular focus on post-graduate development. Much of our educational role will continue to be achieved through publishing expanded review articles by leaders in their field.
Articles in related areas to surgery and dentistry, such as healthcare management and education, are also welcomed. We aim to educate, entertain, give insight into new surgical techniques and technology, and provide a forum for debate and discussion.
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