M. A. Tambovsky, A. M. Aimaletdinov, E. Yu. Zakirova
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Current Trends in the Application of Stem Cells and Their Derivatives in Animal Sperm Cryopreservation
Sperm cryopreservation is an important part of preserving the germ cells of various organisms. However, when gametes are frozen, various damage often occur, which have a significant impact in artificial insemination. After thawing, spermatozoa usually have ultrastructural, biochemical, and functional changes such as damage of cell membrane and chromatin and oxidative stress. Since spermatozoa have a limited capacity for biosynthetic activity, they have a low capacity for regeneration. The current trend is to improve sperm cryopreservation using natural extracellular vesicles and stem cells. Extracellular vesicles and stem cells have potential regenerative effects because they contain various bioactive molecules to affect sperm repair. The present review focuses on current strategies to improve sperm health after cryopreservation. In particular, this review describes the results of studies on the use of extracellular vesicles and stem cells as cryoprotectants during sperm freezing and thawing.
期刊介绍：
Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology is an international peer reviewed journal that publishes original articles on physical, chemical, and molecular mechanisms that underlie basic properties of biological membranes and mediate membrane-related cellular functions. The primary topics of the journal are membrane structure, mechanisms of membrane transport, bioenergetics and photobiology, intracellular signaling as well as membrane aspects of cell biology, immunology, and medicine. The journal is multidisciplinary and gives preference to those articles that employ a variety of experimental approaches, basically in biophysics but also in biochemistry, cytology, and molecular biology. The journal publishes articles that strive for unveiling membrane and cellular functions through innovative theoretical models and computer simulations.
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