生物工厂：在合成生物学的自动化和生物制造之间架起桥梁

IF 2.5 4区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biotechnology and Bioprocess Engineering Pub Date : 2023-12-11 DOI:10.1007/s12257-023-0226-x

Dae-Hee Lee, Haseong Kim, Bong-Hyun Sung, Byung Kwan Cho, Seung-Goo Lee

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引用次数: 0

摘要

生物工厂是先进的自动化设施，对于简化生物制造和合成生物学中的 "设计-制造-测试-学习"（DBTL）模式至关重要，既适用于学术研究，也适用于工业应用。然而，建立这样一个平台需要大量的财力和时间资源，同时还要在自动化、设备兼容性和运行效率方面保持前瞻性。尽管挑战重重，但全球生物工厂之间的国际合作可以提供解决方案。生物工厂的自动化 DBTL 框架改变了利用工程微生物生产生物产品的方式。随着该领域的发展，生物熔炉对于简化和标准化生物技术流程、解决效率、成本和一致性挑战至关重要。

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Biofoundries: Bridging Automation and Biomanufacturing in Synthetic Biology

Biofoundries represent advanced automation facilities pivotal for streamlining the Design-Build-Test-Learn (DBTL) paradigm in biomanufacturing and synthetic biology, suitable for both academic research and industrial applications. Nonetheless, establishing such a platform demands significant financial and temporal resources while maintaining a forward-looking perspective on automation, equipment compatibility, and operational efficiency. Despite its challenges, international collaborations between global biofoundries may offer solutions. The automated DBTL framework in biofoundries has transformed the production of bioproducts using engineered microbes. As the field advances, biofoundries are essential for streamlining and standardizing biotechnological processes, addressing efficiency, cost, and consistency challenges.

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来源期刊

Biotechnology and Bioprocess Engineering 工程技术-生物工程与应用微生物

CiteScore

5.00

自引率

12.50%

发文量

审稿时长

3 months

期刊介绍： Biotechnology and Bioprocess Engineering is an international bimonthly journal published by the Korean Society for Biotechnology and Bioengineering. BBE is devoted to the advancement in science and technology in the wide area of biotechnology, bioengineering, and (bio)medical engineering. This includes but is not limited to applied molecular and cell biology, engineered biocatalysis and biotransformation, metabolic engineering and systems biology, bioseparation and bioprocess engineering, cell culture technology, environmental and food biotechnology, pharmaceutics and biopharmaceutics, biomaterials engineering, nanobiotechnology, and biosensor and bioelectronics.