Jenine Leal, Ye Shen, Peter Faris, Bruce Dalton, Deana Sabuda, Wrechelle Ocampo, Lauren Bresee, Blanda Chow, Jared R. Fletcher, Elizabeth Henderson, Jaime Kaufman, Joseph Kim, Maitreyi Raman, Scott Kraft, Nicole C. Lamont, Oscar Larios, Bayan Missaghi, Jayna Holroyd-Leduc, Thomas Louie, John Conly
{"title":"Bio-K+ 预防艰难梭菌感染的效果：阶梯式群组随机对照试验","authors":"Jenine Leal, Ye Shen, Peter Faris, Bruce Dalton, Deana Sabuda, Wrechelle Ocampo, Lauren Bresee, Blanda Chow, Jared R. Fletcher, Elizabeth Henderson, Jaime Kaufman, Joseph Kim, Maitreyi Raman, Scott Kraft, Nicole C. Lamont, Oscar Larios, Bayan Missaghi, Jayna Holroyd-Leduc, Thomas Louie, John Conly","doi":"10.1017/ice.2023.169","DOIUrl":null,"url":null,"abstract":"<span>Objective:</span><p>To evaluate the impact of administering probiotics to prevent <span>Clostridioides difficile</span> infection (CDI) among patients receiving therapeutic antibiotics.</p><span>Design:</span><p>Stepped-wedge cluster-randomized trial between September 1, 2016, and August 31, 2019.</p><span>Setting:</span><p>This study was conducted in 4 acute-care hospitals across an integrated health region.</p><span>Patients:</span><p>Hospitalized patients, aged ≥55 years.</p><span>Methods:</span><p>Patients were given 2 probiotic capsules daily (Bio-K+, Laval, Quebec, Canada), containing 50 billion colony-forming units of <span>Lactobacillus acidophilus</span> CL1285, <span>L. casei</span> LBC80R, and <span>L. rhamnosus</span> CLR2. We measured hospital-acquired CDI (HA-CDI) and the number of positive <span>C. difficile</span> tests per 10,000 patient days as well as adherence to administration of Bio-K+ within 48 and 72 hours of antibiotic administration. Mixed-effects generalized linear models, adjusted for influenza admissions and facility characteristics, were used to evaluate the impact of the intervention on outcomes.</p><span>Results:</span><p>Overall adherence of Bio-K+ administration ranged from 76.9% to 84.6% when stratified by facility and periods. Rates of adherence to administration within 48 and 72 hours of antibiotic treatment were 60.2% –71.4% and 66.7%–75.8%, respectively. In the adjusted analysis, there was no change in HA-CDI (incidence rate ratio [IRR], 0.92; 95% confidence interval [CI], 0.68–1.23) or <span>C. difficile</span> positivity rate (IRR, 1.05; 95% CI, 0.89–1.24). Discharged patients may not have received a complete course of Bio-K+. Our hospitals had a low baseline incidence of HA-CDI. Patients who did not receive Bio-K+ may have differential risks of acquiring CDI, introducing selection bias.</p><span>Conclusions:</span><p>Hospitals considering probiotics as a primary prevention strategy should consider the baseline incidence of HA-CDI in their population and timing of probiotics relative to the start of antimicrobial administration.</p>","PeriodicalId":13558,"journal":{"name":"Infection Control & Hospital Epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effectiveness of Bio-K+ for the prevention of Clostridioides difficile infection: Stepped-wedge cluster-randomized controlled trial\",\"authors\":\"Jenine Leal, Ye Shen, Peter Faris, Bruce Dalton, Deana Sabuda, Wrechelle Ocampo, Lauren Bresee, Blanda Chow, Jared R. Fletcher, Elizabeth Henderson, Jaime Kaufman, Joseph Kim, Maitreyi Raman, Scott Kraft, Nicole C. Lamont, Oscar Larios, Bayan Missaghi, Jayna Holroyd-Leduc, Thomas Louie, John Conly\",\"doi\":\"10.1017/ice.2023.169\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<span>Objective:</span><p>To evaluate the impact of administering probiotics to prevent <span>Clostridioides difficile</span> infection (CDI) among patients receiving therapeutic antibiotics.</p><span>Design:</span><p>Stepped-wedge cluster-randomized trial between September 1, 2016, and August 31, 2019.</p><span>Setting:</span><p>This study was conducted in 4 acute-care hospitals across an integrated health region.</p><span>Patients:</span><p>Hospitalized patients, aged ≥55 years.</p><span>Methods:</span><p>Patients were given 2 probiotic capsules daily (Bio-K+, Laval, Quebec, Canada), containing 50 billion colony-forming units of <span>Lactobacillus acidophilus</span> CL1285, <span>L. casei</span> LBC80R, and <span>L. rhamnosus</span> CLR2. We measured hospital-acquired CDI (HA-CDI) and the number of positive <span>C. difficile</span> tests per 10,000 patient days as well as adherence to administration of Bio-K+ within 48 and 72 hours of antibiotic administration. Mixed-effects generalized linear models, adjusted for influenza admissions and facility characteristics, were used to evaluate the impact of the intervention on outcomes.</p><span>Results:</span><p>Overall adherence of Bio-K+ administration ranged from 76.9% to 84.6% when stratified by facility and periods. Rates of adherence to administration within 48 and 72 hours of antibiotic treatment were 60.2% –71.4% and 66.7%–75.8%, respectively. In the adjusted analysis, there was no change in HA-CDI (incidence rate ratio [IRR], 0.92; 95% confidence interval [CI], 0.68–1.23) or <span>C. difficile</span> positivity rate (IRR, 1.05; 95% CI, 0.89–1.24). Discharged patients may not have received a complete course of Bio-K+. 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Patients who did not receive Bio-K+ may have differential risks of acquiring CDI, introducing selection bias.</p><span>Conclusions:</span><p>Hospitals considering probiotics as a primary prevention strategy should consider the baseline incidence of HA-CDI in their population and timing of probiotics relative to the start of antimicrobial administration.</p>\",\"PeriodicalId\":13558,\"journal\":{\"name\":\"Infection Control & Hospital Epidemiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-12-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Infection Control & Hospital Epidemiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1017/ice.2023.169\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infection Control & Hospital Epidemiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1017/ice.2023.169","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effectiveness of Bio-K+ for the prevention of Clostridioides difficile infection: Stepped-wedge cluster-randomized controlled trial
Objective:
To evaluate the impact of administering probiotics to prevent Clostridioides difficile infection (CDI) among patients receiving therapeutic antibiotics.
Design:
Stepped-wedge cluster-randomized trial between September 1, 2016, and August 31, 2019.
Setting:
This study was conducted in 4 acute-care hospitals across an integrated health region.
Patients:
Hospitalized patients, aged ≥55 years.
Methods:
Patients were given 2 probiotic capsules daily (Bio-K+, Laval, Quebec, Canada), containing 50 billion colony-forming units of Lactobacillus acidophilus CL1285, L. casei LBC80R, and L. rhamnosus CLR2. We measured hospital-acquired CDI (HA-CDI) and the number of positive C. difficile tests per 10,000 patient days as well as adherence to administration of Bio-K+ within 48 and 72 hours of antibiotic administration. Mixed-effects generalized linear models, adjusted for influenza admissions and facility characteristics, were used to evaluate the impact of the intervention on outcomes.
Results:
Overall adherence of Bio-K+ administration ranged from 76.9% to 84.6% when stratified by facility and periods. Rates of adherence to administration within 48 and 72 hours of antibiotic treatment were 60.2% –71.4% and 66.7%–75.8%, respectively. In the adjusted analysis, there was no change in HA-CDI (incidence rate ratio [IRR], 0.92; 95% confidence interval [CI], 0.68–1.23) or C. difficile positivity rate (IRR, 1.05; 95% CI, 0.89–1.24). Discharged patients may not have received a complete course of Bio-K+. Our hospitals had a low baseline incidence of HA-CDI. Patients who did not receive Bio-K+ may have differential risks of acquiring CDI, introducing selection bias.
Conclusions:
Hospitals considering probiotics as a primary prevention strategy should consider the baseline incidence of HA-CDI in their population and timing of probiotics relative to the start of antimicrobial administration.
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