Ying Shen, Xianfeng Shan, Iniobong P. Etim, Muhammad Ali Siddiqui, Yang Yang, Zewen Shi, Xuping Su, Junxiu Chen
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引用次数: 0
摘要
本研究系统地考察了挤压镁合金上纳米氧化铜和氧化锌微弧氧化（MAO）涂层的降解、抗菌效果和生物相容性。铜（Cu）和锌（Zn）都具有抗菌特性。研究结果表明，加入氧化锌会显著降低 MAO 涂层合金的降解率，因为其具有自封微孔。CuO + MAO 涂层具有优异的抗菌性能，在与金黄色葡萄球菌共培养 6 小时内，抗菌率超过 90%。同样，ZnO + MAO 涂层的抗菌率在共培养 12 小时后也达到了 90%。使用 MG63 细胞进行的细胞毒性测试表明，CuO 和 ZnO 的加入并没有明显影响涂层的细胞存活率。此外，培养 14 天后，CuO + MAO 和 ZnO + MAO 涂层样品的碱性磷酸酶（ALP）活性高于 MAO 涂层和未涂层样品，这表明涂层具有良好的成骨特性。
Comparative Study of the Effects of Nano ZnO and CuO on the Biodegradation, Biocompatibility, and Antibacterial Properties of Micro-arc Oxidation Coating of Magnesium Alloy
This research systematically examined the degradation, antibacterial effects, and biocompatibility of micro-arc oxidation (MAO) coatings with nano CuO and ZnO on extruded Mg alloys. Both copper (Cu) and Zinc (Zn) possess antibacterial properties. The findings demonstrated that adding ZnO will appreciably reduce the degradation rate of MAO-coating alloy due to the self-sealing micro holes. CuO + MAO coating exhibited excellent antibacterial performance, with an antibacterial rate of over 90% within 6 h co-cultured with Staphylococcus aureus. Similarly, the antibacterial rate of ZnO + MAO coating reached 90% after 12 h co-culture. Cytotoxicity test using MG63 cell indicated that the incorporation of CuO and ZnO did not notably affect the cell viability rate of the coating. Moreover, after 14 days of culture, the CuO + MAO and ZnO + MAO coated samples exhibited higher alkaline phosphatase (ALP) activity than the MAO-coated and uncoated samples, suggesting favorable osteogenic properties.
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This international journal presents compact reports of significant, original and timely research reflecting progress in metallurgy, materials science and engineering, including materials physics, physical metallurgy, and process metallurgy.
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