近距离观察脂质双分子层中的热量测定下转变

IF 3.4 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Sophia A. Korono, John F. Nagle
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引用次数: 0

摘要

我们利用差示扫描量热法重新研究了单胶束囊泡的热行为,以探讨在波纹阶段的理论和模拟中是否必须包括相邻双层膜之间的相互作用。这个问题的重点是多胶束囊泡 (MLV) 中的低级阶段(又称过渡前阶段)和明显存在于低级阶段和主要过渡阶段之间的波纹阶段。我们发现单淀粉囊泡 (ULV) 中的异常热行为始于与多淀粉囊泡中低级转变相同的温度,但与多淀粉囊泡中的低级转变相比,这一特征被大大拓宽,而且略微减弱。我们将此归因于在小球上堆积规则波纹图案的困难。我们得出结论,相邻双层膜之间的相互作用对于脂质双层膜中的波纹相并不重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Closer look at the calorimetric lower transition in lipid bilayers

The thermal behavior of unilamellar vesicles has been revisited with differential scanning calorimetry to address the issue of whether it is essential to include interactions between neighboring bilayers in theories and simulations of the ripple phase. The issue focuses on the lower, aka pretransition, and the ripple phase that clearly exists between the lower and main transitions in multilamellar vesicles (MLV). We find anomalous thermal behavior in unilamellar vesicles (ULV) beginning at the same temperature as the lower transition in MLVs, but this feature is considerably broadened and somewhat weaker compared to the lower transition in MLVs. We ascribe this to the difficulty of packing a regular ripple pattern on small spheres. In agreement with a few reports of a ripple phase in direct images of single bilayers, we conclude that interactions between neighboring bilayers are not essential for the ripple phase in lipid bilayers.

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来源期刊
Chemistry and Physics of Lipids
Chemistry and Physics of Lipids 生物-生化与分子生物学
CiteScore
7.60
自引率
2.90%
发文量
50
审稿时长
40 days
期刊介绍: Chemistry and Physics of Lipids publishes research papers and review articles on chemical and physical aspects of lipids with primary emphasis on the relationship of these properties to biological functions and to biomedical applications. Accordingly, the journal covers: advances in synthetic and analytical lipid methodology; mass-spectrometry of lipids; chemical and physical characterisation of isolated structures; thermodynamics, phase behaviour, topology and dynamics of lipid assemblies; physicochemical studies into lipid-lipid and lipid-protein interactions in lipoproteins and in natural and model membranes; movement of lipids within, across and between membranes; intracellular lipid transfer; structure-function relationships and the nature of lipid-derived second messengers; chemical, physical and functional alterations of lipids induced by free radicals; enzymatic and non-enzymatic mechanisms of lipid peroxidation in cells, tissues, biofluids; oxidative lipidomics; and the role of lipids in the regulation of membrane-dependent biological processes.
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