A. A. Akishina, R. O. Cherezov, Y. E. Vorontsova, O. B. Simonova
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Effect of the Histone Deacetylase (HDAC) Inhibitor Belinostat on the Expression of the Aryl Hydrocarbon Receptor and its Target Genes in Human Cell Cultures
Abstract
Aryl hydrocarbon receptor (AHR) is a highly conserved ligand-dependent transcription factor, whose target genes play a key role in detoxification, regulation of developmental processes, maintenance of eukaryotic homeostasis, and metabolism of medicinal compounds. This study demonstrates for the first time an increase in the expression of the aryl hydrocarboxylic receptor gene and its target genes in human cell cultures after exposure to a histone deacetylase inhibitor (belinostat), which is currently being considered as a possible therapeutic agent for the treatment of various types of gliomas, including glioblastomas.
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