谷胱甘肽碳点作为细胞内活性氧清除剂减少顺铂诱导的耳毒性

IF 9.7 4区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS
VIEW Pub Date : 2023-11-27 DOI:10.1002/viw.20230056
Yaqin Tu, Guorun Fan, Nan Wu, Bo Liu, Haiying Sun, Qiong Wang, Wenqing Zou, Hongjun Xiao, Songwei Tan
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引用次数: 0

摘要

人们普遍认为铂类化疗,特别是顺铂类化疗可引起耳毒性。目前,还没有食品药品监督管理局批准的预防或减轻耳毒性的药物。耳毒性通常被认为是由内耳产生过多的活性氧引起的。因此,人们开发了多种抗氧化剂来防止耳毒性。为了提高药物在耳蜗的传递效率,我们合成了简单、易于获得的超小尺寸谷胱甘肽碳点(GSH CDs)。实验结果表明,GSH cd具有较强的自由基清除活性,可恢复线粒体功能,维持毛细胞稳定性,保护毛细胞免受顺铂诱导的氧化应激。因此,谷胱甘肽cd可作为预防顺铂所致耳毒性的新型治疗剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Glutathione carbon dots as an intracellular reactive oxygen species scavenger for reducing cisplatin-induced ototoxicity

Glutathione carbon dots as an intracellular reactive oxygen species scavenger for reducing cisplatin-induced ototoxicity
It is widely recognized that platinum-based chemotherapy, particularly cisplatin therapy, can cause ototoxicity. At present, there are no Food and Drug Administration-approved drugs to prevent or alleviate ototoxicity. Ototoxicity is generally believed to be caused by excessive reactive oxygen species production in the inner ear. Accordingly, a variety of antioxidants have been developed to protect against ototoxicity. To improve the efficiency of drug delivery to the cochlea, here, we synthesized simple and easy-to-obtain glutathione carbon dots (GSH CDs) with ultra-small dimensions. The experimental results revealed that the GSH CDs have strong free-radical scavenging activity and can restore mitochondrial function, maintain hair cell stability, and protect hair cells from cisplatin-induced oxidative stress. Thus, GSH CDs may serve as a new therapeutic agent for preventing cisplatin-induced ototoxicity.
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来源期刊
VIEW
VIEW Multiple-
CiteScore
12.60
自引率
2.30%
发文量
0
审稿时长
10 weeks
期刊介绍: View publishes scientific articles studying novel crucial contributions in the areas of Biomaterials and General Chemistry. View features original academic papers which go through peer review by experts in the given subject area.View encourages submissions from the research community where the priority will be on the originality and the practical impact of the reported research.
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