Yumei Huo , Beibei Chen , Xiaoyu Ren , Chao Wang , Rupeng Qi , Zhaoqing Xu
{"title":"可见光诱导对映选择性C(sp3)-H烷基化不对称合成手性杂酶胺","authors":"Yumei Huo , Beibei Chen , Xiaoyu Ren , Chao Wang , Rupeng Qi , Zhaoqing Xu","doi":"10.1016/j.gresc.2023.11.004","DOIUrl":null,"url":null,"abstract":"<div><div>The chiral heterobenzylic amines, such as <em>α</em>-alkyl substituted chiral oxadiazole methylamine skeletons are widely present in pesticides and pharmaceuticals, due to their unique biological activities. The enantioselective C(sp<sup>3</sup>)-H alkylation of heterobenzylic amines is an important strategy for the synthesis of <em>α</em>-alkylate chiral heterobenzylic amines. Herein, we disclose the first example of photoinduced and Cu-catalyzed enantioselective decarboxylative C(sp<sup>3</sup>)-H alkylation of oxadiazole methylamines.</div></div>","PeriodicalId":12794,"journal":{"name":"Green Synthesis and Catalysis","volume":"6 1","pages":"Pages 114-118"},"PeriodicalIF":0.0000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Asymmetric synthesis of chiral heterobenzylic amines via visible-light-induced enantioselective C(sp3)-H alkylation\",\"authors\":\"Yumei Huo , Beibei Chen , Xiaoyu Ren , Chao Wang , Rupeng Qi , Zhaoqing Xu\",\"doi\":\"10.1016/j.gresc.2023.11.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The chiral heterobenzylic amines, such as <em>α</em>-alkyl substituted chiral oxadiazole methylamine skeletons are widely present in pesticides and pharmaceuticals, due to their unique biological activities. The enantioselective C(sp<sup>3</sup>)-H alkylation of heterobenzylic amines is an important strategy for the synthesis of <em>α</em>-alkylate chiral heterobenzylic amines. Herein, we disclose the first example of photoinduced and Cu-catalyzed enantioselective decarboxylative C(sp<sup>3</sup>)-H alkylation of oxadiazole methylamines.</div></div>\",\"PeriodicalId\":12794,\"journal\":{\"name\":\"Green Synthesis and Catalysis\",\"volume\":\"6 1\",\"pages\":\"Pages 114-118\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Green Synthesis and Catalysis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666554923000984\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Green Synthesis and Catalysis","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666554923000984","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Asymmetric synthesis of chiral heterobenzylic amines via visible-light-induced enantioselective C(sp3)-H alkylation
The chiral heterobenzylic amines, such as α-alkyl substituted chiral oxadiazole methylamine skeletons are widely present in pesticides and pharmaceuticals, due to their unique biological activities. The enantioselective C(sp3)-H alkylation of heterobenzylic amines is an important strategy for the synthesis of α-alkylate chiral heterobenzylic amines. Herein, we disclose the first example of photoinduced and Cu-catalyzed enantioselective decarboxylative C(sp3)-H alkylation of oxadiazole methylamines.