Advances in transcriptomic analysis of Salmonella biofilms and their correlation with food safety

Salmonella, a Gram-negative Enterobacteriaceae bacterium, is a common foodborne pathogen that causes diarrhea. Biofilms produced by Salmonella adhere to food and utensil surfaces, making it challenging to disrupt toxin production. Preventing biofilm formation and eliminating established biofilms are crucial for ensuring food safety. Understanding the mechanisms underlying biofilm formation is fundamental for controlling Salmonella contamination. The use of transcriptomic technologies, such as RNA sequencing, enables the examination of variations in gene expression in diverse environments and growth conditions at the RNA level, thereby serving as an approach to analyze and delineate the fundamental Salmonella biofilm formation mechanisms. This study reviewed the mechanisms of Salmonella biofilm formation from a transcriptomics perspective and proposed potential methods for biofilm analysis and management.