膝关节软骨在磁共振成像上的改变:我们应该合并还是分割地形区域?一项来自骨关节炎倡议的为期两年的数据研究。

IF 2.3 4区 医学 Q1 ANATOMY & MORPHOLOGY
Clinical Anatomy Pub Date : 2023-12-06 DOI:10.1002/ca.24127
Michael J. Richard, Grace H. Lo, Jeffrey B. Driban, Amanda R. Canavatchel, Michael LaValley, Ming Zhang, Lori Lyn Price, Eric Miller, Charles B. Eaton, Timothy E. McAlindon
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引用次数: 0

摘要

目的:我们挑战的范式,一个简单的方法评估解剖区域(例如,内侧股骨或胫骨)是理想的评估关节软骨损失的磁共振(MR)成像。我们使用数据驱动的方法来探索膝关节软骨丢失的特定地形位置是否可以识别当前评估策略所遗漏的随着时间推移的软骨丢失的新模式。设计:我们评估了99个膝关节样本的60个位置特定的关节软骨测量,这些样本具有基线和来自骨关节炎倡议的24个月MR图像,被选为一组极有可能发生变化的样本。我们通过两种方式对这些措施的变化进行了因素分析:(1)将这些措施汇总起来,为六个基于解剖区域的总结(解剖区域;例如,胫骨内侧)和(2)分别治疗每个部位,总共进行60次测量(针对特定部位的测量)。结果:第一次分析产生了三个因素,占24个月随访期间发生的关节软骨变化的66%:(1)胫股内侧,(2)髌骨内侧和外侧,(3)胫股外侧。第二种方法产生了20个因素,占软骨变化差异的75%。12个因素只涉及一个解剖区域。五个因素包括邻近地区的位置(由第一个分析定义;例如,内侧胫股)。三个因素包括不同部位的关节软骨损失。结论:软骨损失的新模式发生在每个解剖区域和跨越这些区域,包括在不同的区域。传统的解剖区域方法更容易实现和解释,但可能会模糊有意义的变化模式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Knee cartilage change on magnetic resonance imaging: Should we lump or split topographical regions? A 2-year study of data from the osteoarthritis initiative

Objective

We challenge the paradigm that a simplistic approach evaluating anatomic regions (e.g., medial femur or tibia) is ideal for assessing articular cartilage loss on magnetic resonance (MR) imaging. We used a data-driven approach to explore whether specific topographical locations of knee cartilage loss may identify novel patterns of cartilage loss over time that current assessment strategies miss.

Design

We assessed 60 location-specific measures of articular cartilage on a sample of 99 knees with baseline and 24-month MR images from the Osteoarthritis Initiative, selected as a group with a high likelihood to change. We performed factor analyses of the change in these measures in two ways: (1) summing the measures to create one measure for each of the six anatomically regional-based summary (anatomic regions; e.g., medial tibia) and (2) treating each location separately for a total of 60 measures (location-specific measures).

Results

The first analysis produced three factors accounting for 66% of the variation in the articular cartilage changes that occur over 24 months of follow-up: (1) medial tibiofemoral, (2) medial and lateral patellar, and (3) lateral tibiofemoral. The second produced 20 factors accounting for 75% of the variance in cartilage changes. Twelve factors only involved one anatomic region. Five factors included locations from adjoining regions (defined by the first analysis; e.g., medial tibiofemoral). Three factors included articular cartilage loss from disparate locations.

Conclusions

Novel patterns of cartilage loss occur within each anatomic region and across these regions, including in disparate regions. The traditional anatomic regional approach is simpler to implement and interpret but may obscure meaningful patterns of change.

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来源期刊
Clinical Anatomy
Clinical Anatomy 医学-解剖学与形态学
CiteScore
5.50
自引率
12.50%
发文量
154
审稿时长
3 months
期刊介绍: Clinical Anatomy is the Official Journal of the American Association of Clinical Anatomists and the British Association of Clinical Anatomists. The goal of Clinical Anatomy is to provide a medium for the exchange of current information between anatomists and clinicians. This journal embraces anatomy in all its aspects as applied to medical practice. Furthermore, the journal assists physicians and other health care providers in keeping abreast of new methodologies for patient management and informs educators of new developments in clinical anatomy and teaching techniques. Clinical Anatomy publishes original and review articles of scientific, clinical, and educational interest. Papers covering the application of anatomic principles to the solution of clinical problems and/or the application of clinical observations to expand anatomic knowledge are welcomed.
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