Lieke Bakker , Kyonghwan Choe , Simone J.P.M. Eussen , Inez H.G.B. Ramakers , Daniel L.A. van den Hove , Gunter Kenis , Bart P.F. Rutten , Frans R.J. Verhey , Sebastian Köhler
{"title":"犬尿氨酸通路与正常年龄关系的系统综述。","authors":"Lieke Bakker , Kyonghwan Choe , Simone J.P.M. Eussen , Inez H.G.B. Ramakers , Daniel L.A. van den Hove , Gunter Kenis , Bart P.F. Rutten , Frans R.J. Verhey , Sebastian Köhler","doi":"10.1016/j.mad.2023.111890","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>The kynurenine pathway (KP) is gaining more attention as a common pathway involved in age-related conditions. However, which changes in the KP occur due to normal ageing is still largely unclear. The aim of this systematic review was to summarize the available evidence for associations of KP metabolites with age.</p></div><div><h3>Methods</h3><p>We used an broad search strategy and included studies up to October 2023.</p></div><div><h3>Results</h3><p>Out of 8795 hits, 55 studies were eligible for the systematic review. These studies suggest that blood levels of tryptophan decrease with age, while blood and cerebrospinal fluid levels of kynurenine and its ratio with tryptophan increase. Studies investigating associations between cerebrospinal fluid and blood levels of kynurenic acid and quinolinic acid with age reported either positive or non-significant findings. However, there is a large heterogeneity across studies. Additionally, most studies were cross-sectional, and only few studies investigated associations with other downstream kynurenines.</p></div><div><h3>Conclusions</h3><p>This systematic review suggests that levels of kynurenines are positively associated with age. Larger and prospective studies are needed that also investigate a more comprehensive panel of KP metabolites and changes during the life-course.</p></div>","PeriodicalId":18340,"journal":{"name":"Mechanisms of Ageing and Development","volume":"217 ","pages":"Article 111890"},"PeriodicalIF":5.3000,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0047637423001161/pdfft?md5=c1859406aaa5400080ec3acd87b31d2e&pid=1-s2.0-S0047637423001161-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Relation of the kynurenine pathway with normal age: A systematic review\",\"authors\":\"Lieke Bakker , Kyonghwan Choe , Simone J.P.M. Eussen , Inez H.G.B. Ramakers , Daniel L.A. van den Hove , Gunter Kenis , Bart P.F. Rutten , Frans R.J. Verhey , Sebastian Köhler\",\"doi\":\"10.1016/j.mad.2023.111890\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>The kynurenine pathway (KP) is gaining more attention as a common pathway involved in age-related conditions. However, which changes in the KP occur due to normal ageing is still largely unclear. The aim of this systematic review was to summarize the available evidence for associations of KP metabolites with age.</p></div><div><h3>Methods</h3><p>We used an broad search strategy and included studies up to October 2023.</p></div><div><h3>Results</h3><p>Out of 8795 hits, 55 studies were eligible for the systematic review. These studies suggest that blood levels of tryptophan decrease with age, while blood and cerebrospinal fluid levels of kynurenine and its ratio with tryptophan increase. Studies investigating associations between cerebrospinal fluid and blood levels of kynurenic acid and quinolinic acid with age reported either positive or non-significant findings. However, there is a large heterogeneity across studies. Additionally, most studies were cross-sectional, and only few studies investigated associations with other downstream kynurenines.</p></div><div><h3>Conclusions</h3><p>This systematic review suggests that levels of kynurenines are positively associated with age. 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Relation of the kynurenine pathway with normal age: A systematic review
Background
The kynurenine pathway (KP) is gaining more attention as a common pathway involved in age-related conditions. However, which changes in the KP occur due to normal ageing is still largely unclear. The aim of this systematic review was to summarize the available evidence for associations of KP metabolites with age.
Methods
We used an broad search strategy and included studies up to October 2023.
Results
Out of 8795 hits, 55 studies were eligible for the systematic review. These studies suggest that blood levels of tryptophan decrease with age, while blood and cerebrospinal fluid levels of kynurenine and its ratio with tryptophan increase. Studies investigating associations between cerebrospinal fluid and blood levels of kynurenic acid and quinolinic acid with age reported either positive or non-significant findings. However, there is a large heterogeneity across studies. Additionally, most studies were cross-sectional, and only few studies investigated associations with other downstream kynurenines.
Conclusions
This systematic review suggests that levels of kynurenines are positively associated with age. Larger and prospective studies are needed that also investigate a more comprehensive panel of KP metabolites and changes during the life-course.
期刊介绍：
Mechanisms of Ageing and Development is a multidisciplinary journal aimed at revealing the molecular, biochemical and biological mechanisms that underlie the processes of aging and development in various species as well as of age-associated diseases. Emphasis is placed on investigations that delineate the contribution of macromolecular damage and cytotoxicity, genetic programs, epigenetics and genetic instability, mitochondrial function, alterations of metabolism and innovative anti-aging approaches. For all of the mentioned studies it is necessary to address the underlying mechanisms.
Mechanisms of Ageing and Development publishes original research, review and mini-review articles. The journal also publishes Special Issues that focus on emerging research areas. Special issues may include all types of articles following peered review. Proposals should be sent directly to the Editor-in-Chief.
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