海马体运动记忆网络的重组取决于熟悉程度，而不是时间。

IF 1.8 4区医学 Q4 NEUROSCIENCES

Learning & memory Pub Date : 2023-12-06 Print Date: 2023-12-01 DOI:10.1101/lm.053792.123

D Gregory Sullens, Phuoc Nguyen, Kayla Gilley, Madison B Wiffler, Melanie J Sekeres

{"title":"海马体运动记忆网络的重组取决于熟悉程度，而不是时间。","authors":"D Gregory Sullens, Phuoc Nguyen, Kayla Gilley, Madison B Wiffler, Melanie J Sekeres","doi":"10.1101/lm.053792.123","DOIUrl":null,"url":null,"abstract":"There is debate as to whether a time-dependent transformation of the episodic-like memory network is observed for nonepisodic tasks, including procedural motor memory. To determine how motor memory networks reorganize with time and practice, mice performed a motor task in a straight alley maze for 1 d (recent), 20 d of continuous training (continuous), or testing 20 d after the original training (remote), and then regional c-Fos expression was assessed. Elevated hippocampal c-Fos accompanied remote, but not continuous, motor task retrieval after 20 d, suggesting that the hippocampus remains engaged for nonhabitual remote motor memory retrieval.","PeriodicalId":18003,"journal":{"name":"Learning & memory","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10750863/pdf/","citationCount":"0","resultStr":"{\"title\":\"Hippocampal motor memory network reorganization depends on familiarity, not time.\",\"authors\":\"D Gregory Sullens, Phuoc Nguyen, Kayla Gilley, Madison B Wiffler, Melanie J Sekeres\",\"doi\":\"10.1101/lm.053792.123\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"There is debate as to whether a time-dependent transformation of the episodic-like memory network is observed for nonepisodic tasks, including procedural motor memory. To determine how motor memory networks reorganize with time and practice, mice performed a motor task in a straight alley maze for 1 d (recent), 20 d of continuous training (continuous), or testing 20 d after the original training (remote), and then regional c-Fos expression was assessed. Elevated hippocampal c-Fos accompanied remote, but not continuous, motor task retrieval after 20 d, suggesting that the hippocampus remains engaged for nonhabitual remote motor memory retrieval.\",\"PeriodicalId\":18003,\"journal\":{\"name\":\"Learning & memory\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2023-12-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10750863/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Learning & memory\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1101/lm.053792.123\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/12/1 0:00:00\",\"PubModel\":\"Print\",\"JCR\":\"Q4\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Learning & memory","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1101/lm.053792.123","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/12/1 0:00:00","PubModel":"Print","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

摘要

对于非情景任务，包括程序性运动记忆，是否观察到类情景记忆网络的时间依赖性转换，存在争议。为了确定运动记忆网络如何随着时间和练习而重组，小鼠在直巷迷宫中执行运动任务1 d(近期)，连续训练20 d(连续)或原始训练20 d后测试(远程)，然后评估区域c-Fos表达。20天后，海马c-Fos升高伴随着远端而非连续的运动任务检索，表明海马仍参与非习惯性远端运动记忆检索。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Hippocampal motor memory network reorganization depends on familiarity, not time.

There is debate as to whether a time-dependent transformation of the episodic-like memory network is observed for nonepisodic tasks, including procedural motor memory. To determine how motor memory networks reorganize with time and practice, mice performed a motor task in a straight alley maze for 1 d (recent), 20 d of continuous training (continuous), or testing 20 d after the original training (remote), and then regional c-Fos expression was assessed. Elevated hippocampal c-Fos accompanied remote, but not continuous, motor task retrieval after 20 d, suggesting that the hippocampus remains engaged for nonhabitual remote motor memory retrieval.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Learning & memory 医学-神经科学

CiteScore

3.60

自引率

5.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The neurobiology of learning and memory is entering a new interdisciplinary era. Advances in neuropsychology have identified regions of brain tissue that are critical for certain types of function. Electrophysiological techniques have revealed behavioral correlates of neuronal activity. Studies of synaptic plasticity suggest that some mechanisms of memory formation may resemble those of neural development. And molecular approaches have identified genes with patterns of expression that influence behavior. It is clear that future progress depends on interdisciplinary investigations. The current literature of learning and memory is large but fragmented. Until now, there has been no single journal devoted to this area of study and no dominant journal that demands attention by serious workers in the area, regardless of specialty. Learning & Memory provides a forum for these investigations in the form of research papers and review articles.