光氧化还原辅助酮与芳烯直接a-烷基化反应的研究

IF 1.5 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Helvetica Chimica Acta Pub Date : 2023-11-20 DOI:10.1002/hlca.202300139

Tsubasa Hirata, Tomoya Hisada, Yoshihiro Ogasawara, Shū Kobayashi, Yasuhiro Yamashita

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引用次数: 0

摘要

研究了在有机光催化剂和Brønsted碱的作用下，酮与烯烃的直接a-烷基化反应。结果表明，在2,4,6-三(二苯基氨基)-3,5-二氟苯腈(3DPA2FBN)和LiOtBu的催化量存在下，酮类与苯乙烯类似物的反应在蓝光led照射下顺利进行，可获得中高收率的产物。这种方法构成了环酮和非环酮a功能化的原子经济烷基化过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Development of Photoredox-Assisted Direct α-Alkylation Reactions of Ketones with Arylalkenes Using a Catalytic Amount of LiOtBu as a Brønsted Base

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Development of Photoredox-Assisted Direct α-Alkylation Reactions of Ketones with Arylalkenes Using a Catalytic Amount of LiOtBu as a Brønsted Base

Photoinduced direct α-alkylation reactions of ketones with arylalkenes using an organophotocatalyst and a Brønsted base were developed. It was found that the choice of both Brønsted base and photocatalyst was crucial, and in the presence of catalytic amounts of 2,4,6-tris(diphenylamino)-3,5-difluorobenzonitrile (3DPA2FBN) and LiO^tBu, the desired reactions of ketones with styrene analogues proceeded smoothly under blue-LED light irradiation to afford the products in moderate to high yields. This method constitutes an atom-economical alkylation process for α-functionalization of both cyclic and acyclic ketones.

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来源期刊

Helvetica Chimica Acta 化学-化学综合

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

2.3 months

期刊介绍： Helvetica Chimica Acta, founded by the Swiss Chemical Society in 1917, is a monthly multidisciplinary journal dedicated to the dissemination of knowledge in all disciplines of chemistry (organic, inorganic, physical, technical, theoretical and analytical chemistry) as well as research at the interface with other sciences, where molecular aspects are key to the findings. Helvetica Chimica Acta is committed to the publication of original, high quality papers at the frontier of scientific research. All contributions will be peer reviewed with the highest possible standards and published within 3 months of receipt, with no restriction on the length of the papers and in full color.