2 型糖尿病成人体育锻炼与全因死亡率和心血管死亡率之间的关系:2007-2018年国家健康调查(NHANES)前瞻性队列研究。

IF 2.6 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Jie Lu, Xiting Cao, Xinyu Chang, Guowei Zheng, Hao Zhu, Shuaijie Gao, Zhenwei Wang, Xiaocan Jia, Xuezhong Shi, Yongli Yang
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引用次数: 0

摘要

目的:研究体力活动与2型糖尿病成人全因死亡率和心血管死亡率之间的剂量-反应关系,以及用体力活动替代久坐行为的效果。方法:2007-2018年NHANES纳入了4808名2型糖尿病成人。采用 Cox 比例危险模型计算危险比和 95% 置信区间。还进一步进行了等时替代分析,以确定替代久坐时间可能带来的益处:在中位随访 6.58 年期间,共有 902 人死亡,其中 290 人死于心血管疾病。与不活动组相比,低活动组和高活动组的全因死亡风险[HRs (95% CIs) 分别为 0.64 (0.50, 0.83); 0.60 (0.50, 0.73)]和心血管死亡风险[分别为 0.50 (0.29, 0.88); 0.54 (0.39, 0.76)]有所下降。]剂量-反应分析表明,体育锻炼与全因死亡率和心血管死亡率之间呈明显的 U 型曲线。用体育锻炼替代每天 30 分钟的久坐时间,可大大降低 8% 至 32% 的死亡风险:结论:每周 40.52 和 31.66 MET-h 的高水平体育锻炼分别与最低的全因和心血管死亡风险有关。用体育锻炼取代久坐时间可使 2 型糖尿病患者受益。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations between physical activity and all-cause and cardiovascular mortality in adults with type 2 diabetes mellitus: A prospective cohort study from NHANES 2007–2018

Aims

To investigate the dose-response association between physical activity and all-cause and cardiovascular mortality in adults with type 2 diabetes mellitus and the effects of replacing sedentary behavior with physical activity.

Methods

4808 adults with type 2 diabetes mellitus were included in NHANES 2007–2018. Cox proportional hazards models were used to calculate hazard ratios and 95% confidence intervals. Isotemporal substitution analyses were further to determine the possible benefit of replacing sedentary time.

Results

During a median follow-up of 6.58 years, 902 deaths occurred, including 290 deaths from cardiovascular disease. Compared with the inactive group, the low-active and high-active groups were associated with declined risks of all-cause mortality [HRs (95% CIs) 0.64 (0.50, 0.83); 0.60 (0.50, 0.73), respectively] and cardiovascular mortality [0.50 (0.29, 0.88); 0.54 (0.39, 0.76)), respectively]. Dose-response analysis showed a significant U-shaped curve between physical activity and all-cause and cardiovascular mortality. Replacing 30 min/day of sedentary time with physical activity was substantially linked to a reduced risk of 8–32% mortality.

Conclusion

A high level of PA of 40.52 and 31.66 MET-h/week was respectively related to the lowest risk of all-cause and cardiovascular mortality. Replacing sedentary time with physical activity could benefit the type 2 diabetes mellitus population.

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来源期刊
Primary Care Diabetes
Primary Care Diabetes ENDOCRINOLOGY & METABOLISM-PRIMARY HEALTH CARE
CiteScore
5.00
自引率
3.40%
发文量
134
审稿时长
47 days
期刊介绍: The journal publishes original research articles and high quality reviews in the fields of clinical care, diabetes education, nutrition, health services, psychosocial research and epidemiology and other areas as far as is relevant for diabetology in a primary-care setting. The purpose of the journal is to encourage interdisciplinary research and discussion between all those who are involved in primary diabetes care on an international level. The Journal also publishes news and articles concerning the policies and activities of Primary Care Diabetes Europe and reflects the society''s aim of improving the care for people with diabetes mellitus within the primary-care setting.
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