人类睡眠时的神经再激活

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Dan Denis, Scott A Cairney
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引用次数: 0

摘要

睡眠能促进记忆巩固:这是新获得的记忆得以稳定、强化并融入长期储存的过程。对啮齿类动物的开创性研究表明,睡眠中的记忆再激活是睡眠对记忆产生有益影响的主要机制。在这篇综述中,我们将探讨人类睡眠中记忆再激活过程的证据。汇集在一起的研究支持这样一种观点,即记忆的重新激活发生在人类睡眠期间,并且与巩固记忆的功能相关。电生理学研究表明,记忆再激活与非快速眼动睡眠的主要神经振荡(即慢振荡-纺锤体事件)密切相关。此外,功能成像研究发现,在学习过程中被招募的大脑区域在学习后的睡眠中会被重新激活。总之,目前的证据有力地证明了神经再激活在人类睡眠过程中促进记忆巩固的机理作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neural reactivation during human sleep.

Sleep promotes memory consolidation: the process by which newly acquired memories are stabilised, strengthened, and integrated into long-term storage. Pioneering research in rodents has revealed that memory reactivation in sleep is a primary mechanism underpinning sleep's beneficial effect on memory. In this review, we consider evidence for memory reactivation processes occurring in human sleep. Converging lines of research support the view that memory reactivation occurs during human sleep, and is functionally relevant for consolidation. Electrophysiology studies have shown that memory reactivation is tightly coupled to the cardinal neural oscillations of non-rapid eye movement sleep, namely slow oscillation-spindle events. In addition, functional imaging studies have found that brain regions recruited during learning become reactivated during post-learning sleep. In sum, the current evidence paints a strong case for a mechanistic role of neural reactivation in promoting memory consolidation during human sleep.

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来源期刊
CiteScore
7.70
自引率
0.00%
发文量
94
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