体重指数和伽马间隙对老年冠心病患者心力衰竭和死亡率的协同影响:一项为期 10 年的前瞻性随访研究。

IF 4.6 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Xiaofei Liu, Yangrui Zheng, Da Li, Yali Zhao, Houchen Lv, Lixun Guan, Shihui Fu
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引用次数: 0

摘要

目的:这项为期10年的前瞻性研究旨在分析体重指数(BMI)和伽马间隙对老年冠状动脉疾病(CAD)患者心力衰竭和死亡率的潜在影响:结果:中位年龄为86岁:中位年龄为 86 岁。低体重指数和高伽马间隙的患者发生心力衰竭的比例最高(46.2%),死亡率最高(84.4%),而高体重指数和低伽马间隙的患者发生心力衰竭的比例最低(18.9%),死亡率最低(62.9%)。经过多变量逻辑回归分析的充分调整后,与高 BMI 和低伽马间隙的患者相比,低 BMI 和高伽马间隙的患者最常见心力衰竭(危险比 [HR]:2.82,95% 置信区间 [CI]:1.79-4.48,P<0.05):1.79-4.48, P 结论:低体重指数和高伽马间隙的组合会进一步导致心力衰竭,并增加老年 CAD 患者的死亡率。未来的研究应探讨低体重指数、高伽马间隙和死亡率之间的内在联系,以及营养和免疫干预对改善老年 CAD 患者健康预后的潜在益处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A synergistic impact of body mass index and gamma gap on heart failure and mortality rate among older patients with coronary artery disease: a prospective study with 10-year follow-up.

A synergistic impact of body mass index and gamma gap on heart failure and mortality rate among older patients with coronary artery disease: a prospective study with 10-year follow-up.

Purpose: This prospective study with 10-year follow-up aimed to analyze potential impact of body mass index (BMI) and gamma gap on heart failure and mortality rate in older patients with coronary artery disease (CAD).

Methods: There were 987 consecutive older patients with CAD included and divided into four groups according to BMI and gamma gap levels.

Results: Median age was 86 years. The highest proportion of heart failure (46.2%) and the highest mortality rate (84.4%) was observed in patients with low BMI and high gamma gap, whereas the lowest proportion of heart failure (18.9%) and the lowest mortality rate (62.9%) was observed in those with high BMI and low gamma gap. After full adjustment in multivariate Logistic regression analysis, heart failure was most common in patients with low BMI and high gamma gap compared with those with high BMI and low gamma gap (hazard ratio [HR]: 2.82, 95% confidence interval [CI]: 1.79-4.48, P < 0.05). Meanwhile, multivariate Cox regression analysis showed that mortality rate was the highest in those with low BMI and high gamma gap compared with patients with high BMI and low gamma gap (HR: 1.65, 95% CI: 1.32-2.07, P < 0.05).

Conclusion: The combination of low BMI and high gamma gap could further promote heart failure and increase mortality rate in older patients with CAD. Future studies should explore the underlying mechanisms linking low BMI, high gamma gap, and mortality rate, as well as the potential benefits of nutritional and immunological interventions to improve health prognosis in older patients with CAD.

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来源期刊
Nutrition & Diabetes
Nutrition & Diabetes ENDOCRINOLOGY & METABOLISM-NUTRITION & DIETETICS
CiteScore
9.20
自引率
0.00%
发文量
50
审稿时长
>12 weeks
期刊介绍: Nutrition & Diabetes is a peer-reviewed, online, open access journal bringing to the fore outstanding research in the areas of nutrition and chronic disease, including diabetes, from the molecular to the population level.
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