建模。

IF 2 4区医学 Q3 RESPIRATORY SYSTEM

Journal of Aerosol Medicine and Pulmonary Drug Delivery Pub Date : 2024-02-01 Epub Date: 2023-12-05 DOI:10.1089/jamp.2023.29100.nam

Neil A Miller

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引用次数: 0

摘要

在药物发现和开发过程中，建模已被广泛接受，甚至被寄予厚望。建模可以整合知识，加深理解，并在结果发生之前或无法测量时提供预测能力。这使得建模成为吸入药物的一个有吸引力的选择，因为在像肺这样一个多样而复杂的器官的局部微观部位，不可能对药物发生的情况（药代动力学）和药物产生的影响（药效学）进行常规测量。许多信息（数据和知识）就像一块块拼图，而建模则以科学和机理连贯的方式将这些碎片拼接在一起，从而加深对吸入药物疗效和安全性的理解。

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Modeling.

Modeling is coming to the fore as it is now widely accepted and indeed expected during drug discovery and development. Modeling integrates knowledge, increases understanding and provides the ability to predict an outcome either before it occurs or when it is not possible to measure. This makes modeling an attractive option for inhaled drugs as it is not possible to routinely measure what is occurring to the drug (pharmacokinetics) and what effect the drug is having (pharmacodynamics) at local microscopic sites of such a diverse and complex organ as the lung. Many pieces of information (data and knowledge) exist like the pieces of a jigsaw puzzle and modeling brings the pieces together in a scientific and mechanistically coherent manner to increase understanding of both the efficacy and safety of inhaled drugs.

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来源期刊

Journal of Aerosol Medicine and Pulmonary Drug Delivery 医学-呼吸系统

CiteScore

6.70

自引率

2.90%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Aerosol Medicine and Pulmonary Drug Delivery is the only peer-reviewed journal delivering innovative, authoritative coverage of the health effects of inhaled aerosols and delivery of drugs through the pulmonary system. The Journal is a forum for leading experts, addressing novel topics such as aerosolized chemotherapy, aerosolized vaccines, methods to determine toxicities, and delivery of aerosolized drugs in the intubated patient. Journal of Aerosol Medicine and Pulmonary Drug Delivery coverage includes: Pulmonary drug delivery Airway reactivity and asthma treatment Inhalation of particles and gases in the respiratory tract Toxic effects of inhaled agents Aerosols as tools for studying basic physiologic phenomena.